SCHEDULE 13G/A 0001841619 XXXXXXXX LIVE 1 Common Stock, par value $0.0002 per share 09/30/2025 0001476963 Scorpius Holdings, Inc. 42237K508 1305 E. Houston Street, Building 2 San Antonio TX 78205 Rule 13d-1(c) 3i, LP a DE 0.00 6786087.00 0.00 6786087.00 6786087.00 N 9.9 PN As more fully described in Item 4 of this Amendment No. 1 to Statement on Schedule 13G (this "Amendment No. 1"), such shares and percentage are based on 61,142,712 shares of common stock, par value $0.0002 per share, of the issuer (the ''Common Stock''), outstanding as of August 22, 2025, as disclosed in the issuer's Quarterly Report on Form 10-Q for the period ended March 31, 2025, filed by the issuer with the U.S. Securities and Exchange Commission (the ''SEC'') on August 22, 2025 (the ''Form 10-Q''). Beneficial ownership consists of 6,786,087 shares of Common Stock issuable in any combination upon (i) exercise of certain common stock purchase warrants (the ''Warrants'') held directly by the reporting person, which exercises are subject to a 9.99% beneficial ownership limitation provision (the ''Blocker''), and (ii) conversion of a senior secured convertible note in the principal aggregate amount of approximately $11.4 million (the ''Note'') held directly by the reporting person, conversions of which are subject to a Blocker. 3i Management LLC a DE 0.00 6786087.00 0.00 6786087.00 6786087.00 N 9.9 OO As more fully described in Item 4 of this Amendment No. 1, such shares and percentage are based on 61,142,712 shares of Common Stock outstanding as of August 22, 2025, as disclosed contained in the Form 10-Q. Beneficial ownership consists of 6,786,087 shares of Common Stock issuable in any combination upon (i) exercise of the Warrants held indirectly by the reporting person, which exercises are subject to a Blocker, and (ii) conversion of the Note held indirectly by the reporting person, which conversions are subject to a Blocker. Maier Joshua Tarlow a X1 0.00 6786087.00 0.00 6786087.00 6786087.00 N 9.9 IN As more fully described in Item 4 of this Amendment No. 1, such shares and percentage are based on 61,142,712 shares of Common Stock outstanding as of August 22, 2025, as disclosed in the Form 10-Q. Beneficial ownership consists of 6,786,087 shares of Common Stock issuable in any combination upon (i) exercise of the Warrants held indirectly by the reporting person, which exercises are subject to a Blocker, and (ii) conversion of the Note held indirectly by the reporting person, which conversions are subject to a Blocker. Scorpius Holdings, Inc. 1305 E. Houston Street, Building 2, San Antonio, TX 78205 (i) 3i, LP, a Delaware limited partnership ("3i"); (ii) 3i Management LLC, a Delaware limited liability company ("3i Management''); and (iii) Maier Joshua Tarlow ("Mr. Tarlow"). The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons". Any disclosures herein with respect to persons other than the Reporting Persons are made on information and belief after making inquiry to the appropriate party. The Reporting Persons have entered into a Joint Filing Agreement, a copy of which is filed as Exhibit 1 to the Statement on Schedule 13G filed by the Reporting Persons with the SEC on August 5, 2025 (the "Schedule 13G"), pursuant to which the Reporting Persons have agreed to file this Amendment No. 1 and all subsequent amendments to the Schedule 13G and this Amendment No. 1 jointly in accordance with the provisions of Rule 13d-1(k) of the Act. The filing of this Amendment No. 1 should not be construed in and of itself as an admission by any Reporting Person as to beneficial ownership of the shares of Common Stock reported herein. 2 Wooster Street, 2nd Floor, New York, NY 10013. 3i is a Delaware limited partnership. 3i Management is a Delaware limited liability company. Mr. Tarlow is a citizen of the United States. Y The purpose of this Amendment No. 1 is to amend and supplement the Schedule 13G in order to update the beneficial ownership information on the cover pages and in Item 4 in the Schedule 13G. The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover pages to this Amendment No. 1 and is incorporated herein by reference for each such Reporting Person. The ownership percentages reported are based on 61,142,712 shares of Common Stock outstanding as of August 22, 2025, as disclosed in the Form 10-Q. 3i holds (i) Warrants exercisable for up to 12,566,667 shares of Common Stock, which exercises are subject to a Blocker, and (ii) the Note in the principal aggregate amount of approximately $11.4 million, which conversions are subject to a Blocker. Due to the interaction between the Blockers in each of the Warrants and the Note, 3i may exercise the Warrants for and/or convert the Note into, in any combination, an aggregate of 6,786,087 shares of Common Stock, as a result of the triggering of the applicable Blockers, each of which prohibits 3i from exercising the Warrants for, or converting the Note into, shares of Common Stock if, as a result of such exercise or conversion, 3i, together with its affiliates and any persons acting as a group together with 3i or any of such affiliates, would beneficially own more than 9.99% of the total number of shares of Common Stock then issued and outstanding immediately after giving effect to such exercise or conversion. Consequently, 3i is the beneficial owner of 6,786,087 shares of Common Stock (the "Shares"). 3i has the power to dispose of and the power to vote the Shares beneficially owned by it, which power may be exercised by 3i Management, the manager and general partner of 3i. Mr. Tarlow, as the manager of 3i Management, has shared power to vote and/or dispose of the Shares beneficially owned by each of 3i and 3i Management. Mr. Tarlow does not directly own the Shares. By reason of the provisions of Rule 13d-3 of the Act, Mr. Tarlow may be deemed to beneficially own the Shares beneficially owned by 3i and 3i Management, and 3i Management may be deemed to beneficially own the Shares beneficially owned by 3i. 9.99 % (A) 3i: 0.00 (B) 3i Management: 0.00 (C) Mr. Tarlow: 0.00 (A) 3i: 6,786,087.00 (B) 3i Management: 6,786,087.00 (C) Mr. Tarlow: 6,786,087.00 (A) 3i: 0.00 (B) 3i Management: 0.00 (C) Mr. Tarlow: 0.00 (A) 3i: 6,786,087.00 (B) 3i Management: 6,786,087.00 (C) Mr. Tarlow: 6,786,087.00 Y Y Y N See Exhibit 1 filed with the Schedule 13G. Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. 3i, LP /s/ 3i, LP 11/12/2025 3i Management LLC /s/ 3i Management LLC 11/12/2025 Maier Joshua Tarlow /s/ Maier Joshua Tarlow 11/12/2025 LIST OF EXHIBITS Exhibit No. 1 - Joint Filing Agreement, dated August 5, 2025 (incorporated by reference to Exhibit 1 to the Schedule 13G filed by the Reporting Persons with the SEC on August 5, 2025).