Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2022

Stockholders' Equity

Schedule of common stock warrants by exercise price range

Issuance Date	Number of Shares	Exercise Price		Expiration Date
5/7/2018	403,025	$	11.09	5/8/2023
11/26/2018	313,358	$	11.55	11/26/2023
1/28/2021	31,000	$	5.78	1/28/2023

Schedule of components of stock-based compensation included in net loss

	For the years ended
	December 31,
	2022		2021
Employee stock options	$	2,782,694	$	1,136,843
Non-employee stock options		1,114,894		1,294,279
Employee stock awards		169,571		2,903,463
Non-employee stock awards		18,578		834,396
	$	4,085,737	$	6,168,981

Schedule of stock option valuation assumptions

	2022		2021
Dividend yield	—	%	—	%
Expected volatility	100.85-105.09	%	99.34-104.61	%
Risk-free interest rate	1.95-3.61	%	0.36-1.36	%
Expected lives (years)	5.3-6.1	years	5.0-6.1	years

Schedule of stock option activity

		Weighted				Weighted
		Average		Aggregate		Average
		Exercise		Intrinsic		Remaining
	Shares	Price		Value		Contractual Life
Stock options outstanding at December 31, 2020	1,480,139	$	11.05	$	403,743
Granted	1,674,153		4.65
Exercised	(70,967)		6.53	$	—
Expired	(49,532)		14.26
Forfeited	(79,478)		5.55
Stock options outstanding at December 31, 2021	2,954,315		7.62	$	100,419
Granted	4,307,599		1.10
Exercised	(12,765)		1.30	$	—
Expired	(82,253)		10.20
Forfeited	(130,022)		4.44
Stock options outstanding at December 31, 2022	7,036,874	$	3.67	$	16,842	9.1	Years
Stock options exercisable at December 31, 2022	1,680,455	$	9.63	$	16,841	7.5	Years

Schedule of restricted stock activity

		Weighted
		Average
	Shares	Fair Value
Restricted stock at December 31, 2020	239,928	$	4.02
Granted	678,490		5.09
Vested	(548,248)		4.88
Restricted stock at December 31, 2021	370,170		4.71
Vested	(336,169)		4.86
Restricted stock at December 31, 2022	34,001	$	3.22

Schedule of RSU activity

		Weighted
		Average
	Shares	Fair Value
RSUs at December 31, 2020	1,900	$	26.60
Vested	(1,900)		26.60
RSUs at December 31, 2021	—	$	—