Net Loss Per Share - Reconciliation of Net Loss (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Net Loss Per Share
Net loss	$ (13,094,771)	$ (7,548,225)	$ (31,548,479)	$ (21,791,941)
Net loss: Non-controlling interest	(89,421)	(115,505)	(265,256)	(283,846)
Net loss attributable to Heat Biologics, Inc.	$ (13,005,350)	$ (7,432,720)	$ (31,283,223)	$ (21,508,095)
Weighted-average common shares outstanding, basic (in shares)	25,613,316	25,137,628	25,603,481	24,828,438
Weighted-average common shares outstanding, diluted (in shares)	25,613,316	25,137,628	25,603,481	24,828,438
Net loss per share, basic (in dollars per share)	$ (0.51)	$ (0.30)	$ (1.22)	$ (0.87)
Net loss per share, diluted (in dollars per share)	$ (0.51)	$ (0.30)	$ (1.22)	$ (0.87)