Net Loss Per Share - Reconciliation of Net Loss (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Net Loss Per Share
Net loss	$ (10,263,910)	$ (6,620,576)	$ (18,453,708)	$ (14,243,716)
Net loss: Non-controlling interest	(106,624)	(77,379)	(175,835)	(168,341)
Net loss attributable to Heat Biologics, Inc.	$ (10,157,286)	$ (6,543,197)	$ (18,277,873)	$ (14,075,375)
Weighted-average common shares outstanding, basic (in shares)	25,602,965	25,137,466	25,598,481	24,671,281
Weighted-average common shares outstanding, diluted (in shares)	25,602,965	25,137,466	25,598,481	24,671,281
Net loss per share, basic (in dollars per share)	$ (0.40)	$ (0.26)	$ (0.71)	$ (0.57)
Net loss per share, diluted (in dollars per share)	$ (0.40)	$ (0.26)	$ (0.71)	$ (0.57)