Net Loss Per Share - Reconciliation of Net Loss (Details) - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Net Loss Per Share
Net loss	$ (8,189,798)	$ (7,623,140)
Net loss: Non-controlling interest	(69,211)	(90,962)
Net loss attributable to Heat Biologics, Inc.	$ (8,120,587)	$ (7,532,178)
Weighted-average common shares outstanding, basic (in shares)	25,593,948	24,199,916
Weighted-average common shares outstanding, diluted (in shares)	25,593,948	24,199,916
Net loss per share, basic (in dollars per share)	$ (0.32)	$ (0.31)
Net loss per share, diluted (in dollars per share)	$ (0.32)	$ (0.31)