Stockholders' Equity - Stock Option Activity (Details)	3 Months Ended
	Mar. 31, 2022 USD ($) $ / shares shares
Shares
Stock options outstanding at beginning of period | shares	2,954,315
Granted | shares	78,250
Expired | shares	(542)
Forfeited | shares	(28,109)
Stock options outstanding at end of period | shares	3,003,914
Stock options exercisable at end of period | shares	1,356,824
Weighted Average Exercise Price
Stock options outstanding at beginning of period (in dollars per share) | $ / shares	$ 7.62
Granted (in dollars per share) | $ / shares	2.86
Expired (in dollars per share) | $ / shares	60.90
Forfeited | $ / shares	4.91
Stock options outstanding at end of period (in dollars per share) | $ / shares	7.52
Stock options exercisable at end of period | $ / shares	$ 11.10
Aggregate Intrinsic Value
Stock options outstanding at beginning of period | $	$ 101,306
Stock options outstanding at end of period | $	116,956
Stock options exercisable at end of period | $	$ 62,432
Weighted Average Remaining Contractual Life
Stock options outstanding at end of period	8 years 8 months 12 days
Stock options exercisable at end of period	8 years
Unrecognized stock-based compensation expense | $	$ 5,200,000
Unrecognized stock-based compensation expense, recognition period	1 year 6 months