Net Loss Per Share - Reconciliation of Net Loss (Details) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Net Loss Per Share
Net loss	$ (35,400,807)	$ (26,381,389)
Net loss: Non-controlling interest	(329,339)	(331,652)
Net loss attributable to Heat Biologics, Inc.	$ (35,071,468)	$ (26,049,737)
Weighted-average common shares outstanding, basic (in shares)	24,913,942	15,982,568
Weighted-average common shares outstanding, diluted (in shares)	24,913,942	15,982,568
Net loss per share, basic (in dollars per share)	$ (1.41)	$ (1.63)
Net loss per share, diluted (in dollars per share)	$ (1.49)	$ (1.63)