Stockholders' Equity - Warrants By Exercise Price (Details) - $ / shares	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Number of Shares	2,954,315	1,480,139	437,603
Exercise Price	$ 7.62	$ 11.05	$ 17.90
5/7/2018
Issuance Date	May 07, 2018
Number of Shares	403,025
Exercise Price	$ 11.09
Expiration Date	May 08, 2023
11/26/2018
Issuance Date	Nov. 26, 2018
Number of Shares	313,358
Exercise Price	$ 11.55
Expiration Date	Nov. 26, 2023
1/28/2021
Issuance Date	Jan. 28, 2021
Number of Shares	31,000
Exercise Price	$ 5.78
Expiration Date	Jan. 28, 2023
Common stock warrants
Exercise Price	$ 11.06

Issuance Date of options.

No definition available.

Name:	htbx_ShareBasedCompensationArrangementByShareBasedPaymentAwardIssuanceDate
Namespace Prefix:	htbx_
Data Type:	xbrli:dateItemType
Balance Type:	na
Period Type:	duration

- Definition

Date the equity-based award expires, in YYYY-MM-DD format.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (a)(2)
-URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901

+ Details

Name:	us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpirationDate
Namespace Prefix:	us-gaap_
Data Type:	xbrli:dateItemType
Balance Type:	na
Period Type:	duration

- Definition

Number of options outstanding, including both vested and non-vested options.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(i)-(ii)
-URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901

+ Details

Name:	us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
Namespace Prefix:	us-gaap_
Data Type:	xbrli:sharesItemType
Balance Type:	na
Period Type:	instant

- Definition

Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(i)
-URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901

+ Details

Name:	us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
Namespace Prefix:	us-gaap_
Data Type:	dtr-types:perShareItemType
Balance Type:	na
Period Type:	instant

- Details

Name:	us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=htbx_IssuanceDateFourMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=htbx_IssuanceDateFiveMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=htbx_IssuanceDateSixMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_AwardTypeAxis=htbx_CommonStockWarrantMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type: