Consolidated Statements of Cash Flows - USD ($)	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015
Cash Flows from Operating Activities
Net loss	$ (12,974,799)	$ (21,121,885)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	132,077	115,307
Amortization of deferred financing costs and debt issuance costs	218,827	101,563
Amortization of held to maturity investment premium	32,733	142,442
Stock based compensation	582,630	1,573,602
Increase (decrease) in cash arising from changes in assets and liabilities:
Accounts receivable	(82,440)
Prepaid expenses, restricted cash, and other current assets	532,872	(32,088)
Deposits		(50,000)
Related party receivable	(45,000)	(9,375)
Accounts payable	(1,690,048)	642,332
Accrued expenses and other liabilities	(542,255)	1,040,939
Other long term liabilities	311,686	149,748
Net Cash Used in Operating Activities	(13,523,717)	(17,447,415)
Cash Flows from Investing Activities
Proceeds from maturities of short-term investments	6,656,910	14,956,988
Purchases of short term investments		(11,090,091)
Purchase of property and equipment	(45,936)	(115,506)
Net Cash Provided by Investing Activities	6,610,974	3,751,391
Cash Flows from Financing Activities
Proceeds from public offering, net of underwriting discounts	6,287,250	11,400,870
Proceeds from the issuance of common stock, net of commissions	7,082,526
Proceeds from the exercise of warrants	3,863,429
Stock issuance costs	(488,585)	(302,460)
Proceeds from issuance of long term debt, net		4,470,975
Payments on long term debt	(6,941,821)	(558,179)
Net Cash Provided by Financing Activities	9,802,799	15,011,206
Effect of exchange rate changes on cash and cash equivalents	12,656	(89,531)
Net Increase in Cash and Cash Equivalents	2,902,712	1,225,651
Cash and Cash Equivalents - Beginning of Period	4,939,955	3,714,304
Cash and Cash Equivalents - End of Period	7,842,667	4,939,955
Supplemental Disclosure for Cash Flow Information
Interest paid	330,576	262,066
Supplemental Schedule of Noncash Investing and Financing Activities
Cashless exercise of stock options		$ 32,588