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Summary of Significant Accounting Policies (Details) - USD ($)
3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Dec. 31, 2015
Noncontrolling Interest [Line Items]      
Accumulated a deficit $ (48,990,306)   $ (44,430,703)
Net loss (4,559,603) $ (3,909,198)  
Reclassification amount $ 20,036   $ 22,707
Heat Biologics I, Inc [Member]      
Noncontrolling Interest [Line Items]      
Ownership interest in subsidiary 92.50%   92.50%
Accumulated a deficit $ 4,900,000