<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2016-07-28</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001476170</issuerCik>
        <issuerName>Unilife Corp</issuerName>
        <issuerTradingSymbol>UNIS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001681038</rptOwnerCik>
            <rptOwnerName>Weaver Molly</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>250 CROSS FARM LANE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>YORK</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>17406</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>See Remarks</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>43207</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>43613</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By spouse.</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>48.40</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2021-04-18</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>7500</value>
                    <footnoteId id="F3"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Of these shares of common stock of Unilife Corporation (the &quot;Company&quot;), 594 shares were awarded by the Company to the reporting person on April 14, 2014 and are scheduled to vest on April 30, 2017 subject to the reporting person's continued employment with the Company as of such date.</footnote>
        <footnote id="F2">Of these shares of common stock of the Company, 500 shares were awarded by the Company to the reporting person's spouse on April 15, 2014 and are scheduled to vest on April 30, 2017.  Of these shares, 23,188 represent restricted stock units awarded by the Company to the reporting person's spouse on June 30, 2016, 5,797 of which are scheduled to vest on June 1, 2017, 5,797 of which are scheduled to vest on June 1, 2018, and 11,594 of which are scheduled to vest on June 1, 2019, in each case, subject to the reporting person's continued employment with the Company as of the applicable date.</footnote>
        <footnote id="F3">On April 18, 2011, the reporting person was granted an option to purchase 7,500 shares of common stock of the Company. The option could vest based on the Company's satisfaction of certain performance criteria through April 18, 2021. Certain performance criteria was met in fiscal year 2013, resulting in vesting of the option as to 2,000 shares.</footnote>
    </footnotes>

    <remarks>VP Quality and Regulatory Affairs &amp; CCO</remarks>

    <ownerSignature>
        <signatureName>/s/ Kevin Campbell, as attorney-in-fact</signatureName>
        <signatureDate>2016-08-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
