Exhibit 99.2

JOINT FILING AGREEMENT

In accordance with Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13D (including additional amendments thereto) with respect to the shares of Common Stock, par value $0.001 per share, of Cypress Bioscience, Inc.  This Joint Filing Agreement shall be filed as an Exhibit to such Statement.

Dated:  September 15, 2010

RAMIUS VALUE AND OPPORTUNITY MASTER FUND LTD By:  Ramius Value and Opportunity Advisors LLC,
its investment manager   RAMIUS NAVIGATION MASTER FUND LTD By:  Ramius Advisors, LLC,
its investment advisor   RAMIUS ENTERPRISE MASTER FUND LTD By:  Ramius Advisors, LLC,
its investment advisor   RAMIUS VALUE AND OPPORTUNITY ADVISORS LLC By:  Ramius LLC,
its sole member   RAMIUS OPTIMUM INVESTMENTS LLC By:  Ramius Advisors, LLC,
its managing member RAMIUS V&O ACQUISITION LLC   COWEN OVERSEAS INVESTMENT LP By:  Ramius Advisors, LLC,
its general partner   RAMIUS ADVISORS, LLC By:  Ramius LLC,
its sole member   RAMIUS LLC By:  Cowen Group, Inc.,
its sole member   COWEN GROUP, INC.   RCG HOLDINGS LLC By:  C4S & Co., L.L.C.,
its managing member   C4S & CO., L.L.C.  

By:	/s/ Owen S. Littman
	Name:	Owen S. Littman
	Title:	Authorized Signatory

/s/ Owen S. Littman

OWEN S. LITTMAN

As attorney-in-fact for Jeffrey M. Solomon, Peter A. Cohen, Morgan B. Stark and Thomas W. Strauss