<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001474770</cik>
        <entityName>CRE Strategic Opportunity Fund</entityName>
        <issuerAddress>
            <street1>101 N. MAIN ST</street1>
            <street2>12TH FLOOR</street2>
            <city>GREENVILLE</city>
            <stateOrCountry>SC</stateOrCountry>
            <zipCode>29601</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>864-679-4771</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Limited Liability Company</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2009</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>X</firstName>
                <middleName>X</middleName>
                <lastName>CRE Strategic Opportunity Fund Management, LLC</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>101 N Main St</street1>
                <street2>12th Floor</street2>
                <city>Greenville</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29601</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Manager of the issuer</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>REITS and Finance</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C</item>
            <item>3C.6</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001474770-10-000002</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-11-04</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>25000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>SANDLAPPER Securities, LLC</recipientName>
                <recipientCRDNumber>137906</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>101 N Main St</street1>
                    <street2>12th Floor</street2>
                    <city>Greenville</city>
                    <stateOrCountry>SC</stateOrCountry>
                    <zipCode>29601</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CO</state>
                    <state>FL</state>
                    <state>GA</state>
                    <state>MN</state>
                    <state>NY</state>
                    <state>NC</state>
                    <state>OH</state>
                    <state>OK</state>
                    <state>SC</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>John B. Morris III</recipientName>
                <recipientCRDNumber>5155685</recipientCRDNumber>
                <associatedBDName>Sandlapper Securities, LLC</associatedBDName>
                <associatedBDCRDNumber>137906</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>101 N. Main Street</street1>
                    <street2>12th Floor</street2>
                    <city>Greenville</city>
                    <stateOrCountry>SC</stateOrCountry>
                    <zipCode>29601</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NC</state>
                    <state>SC</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>John Wyatt Boyd</recipientName>
                <recipientCRDNumber>2090782</recipientCRDNumber>
                <associatedBDName>Sandlapper Securities, LLC</associatedBDName>
                <associatedBDCRDNumber>137906</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>101 N. Main Street</street1>
                    <street2>12th Floor</street2>
                    <city>Greenville</city>
                    <stateOrCountry>SC</stateOrCountry>
                    <zipCode>29601</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>GA</state>
                    <state>NC</state>
                    <state>SC</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>John Holmes Ferguson</recipientName>
                <recipientCRDNumber>4947624</recipientCRDNumber>
                <associatedBDName>Steven L. Falk &amp; Associates, Inc.</associatedBDName>
                <associatedBDCRDNumber>14297</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>300 N. Lake Avenue</street1>
                    <street2>#420</street2>
                    <city>Pasadena</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>91101</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>FL</state>
                    <state>NJ</state>
                    <state>NY</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>James Marten Lamont</recipientName>
                <recipientCRDNumber>2846228</recipientCRDNumber>
                <associatedBDName>Independent Financial Group, LLC</associatedBDName>
                <associatedBDCRDNumber>7717</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>1400 Grant Avenue</street1>
                    <street2>#101</street2>
                    <city>Novato</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>94948</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>IA</state>
                    <state>NV</state>
                    <state>NC</state>
                    <state>SC</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Gretchen M. Schorr</recipientName>
                <recipientCRDNumber>704073</recipientCRDNumber>
                <associatedBDName>Independent Financial Group, LLC</associatedBDName>
                <associatedBDCRDNumber>7717</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>32621 Avenida Lestonnac</street1>
                    <city>Temecula</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>92590</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>AZ</state>
                    <state>CA</state>
                    <state>MD</state>
                    <state>OR</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Paul M. Aiesi</recipientName>
                <recipientCRDNumber>5053454</recipientCRDNumber>
                <associatedBDName>Sandlapper Securities, LLC</associatedBDName>
                <associatedBDCRDNumber>137906</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>101 N. Main Street</street1>
                    <street2>12th Floor</street2>
                    <city>Greenville</city>
                    <stateOrCountry>SC</stateOrCountry>
                    <zipCode>29601</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>SC</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Toni Lynn Sutherland</recipientName>
                <recipientCRDNumber>2729672</recipientCRDNumber>
                <associatedBDName>Independent Financial Group, LLC</associatedBDName>
                <associatedBDCRDNumber>7717</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>9039 Soquel Drive</street1>
                    <street2>Ste #2</street2>
                    <city>Aptos</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>95003</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>FL</state>
                    <state>HI</state>
                    <state>NJ</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Orlando C. Fernandez</recipientName>
                <recipientCRDNumber>1980142</recipientCRDNumber>
                <associatedBDName>Harrison Douglas, Inc.</associatedBDName>
                <associatedBDCRDNumber>16515</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>3025 S. Parker Road</street1>
                    <street2>#801</street2>
                    <city>Aurora</city>
                    <stateOrCountry>CO</stateOrCountry>
                    <zipCode>80014</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>AZ</state>
                    <state>CO</state>
                    <state>IN</state>
                    <state>OH</state>
                    <state>VA</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Richard E. Woollen</recipientName>
                <recipientCRDNumber>1342719</recipientCRDNumber>
                <associatedBDName>Harrison Douglas, Inc.</associatedBDName>
                <associatedBDCRDNumber>16515</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>4301 Belknap Road</street1>
                    <city>Charlotte</city>
                    <stateOrCountry>NC</stateOrCountry>
                    <zipCode>28211</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NC</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Steven D. Meahan</recipientName>
                <recipientCRDNumber>1234042</recipientCRDNumber>
                <associatedBDName>Pacific West Securities, Inc.</associatedBDName>
                <associatedBDCRDNumber>6390</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>555 S. Renton Village Place</street1>
                    <street2>STE #700</street2>
                    <city>Renton</city>
                    <stateOrCountry>WA</stateOrCountry>
                    <zipCode>98057</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CO</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Trevor L. Gordon</recipientName>
                <recipientCRDNumber>2195122</recipientCRDNumber>
                <associatedBDName>Sandlapper Securities, LLC</associatedBDName>
                <associatedBDCRDNumber>137906</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>101 N. Main Street</street1>
                    <street2>12th Floor</street2>
                    <city>Greenville</city>
                    <stateOrCountry>SC</stateOrCountry>
                    <zipCode>29601</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CO</state>
                    <state>FL</state>
                    <state>GA</state>
                    <state>MN</state>
                    <state>NY</state>
                    <state>NC</state>
                    <state>OH</state>
                    <state>SC</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Dwight K. Kay</recipientName>
                <recipientCRDNumber>5376903</recipientCRDNumber>
                <associatedBDName>Independent Financial Group</associatedBDName>
                <associatedBDCRDNumber>7717</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>12636 High Bluff Drive</street1>
                    <street2>#100</street2>
                    <city>San Diego</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>92130</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CO</state>
                    <state>NY</state>
                    <state>OH</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>25000000</totalOfferingAmount>
            <totalAmountSold>589500</totalAmountSold>
            <totalRemaining>24410500</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>13</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>2625000</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>250000</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CRE Strategic Opportunity Fund</issuerName>
                <signatureName>Paul M. Aiesi</signatureName>
                <nameOfSigner>Paul M. Aiesi</nameOfSigner>
                <signatureTitle>Vice President</signatureTitle>
                <signatureDate>2010-02-26</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
