X0306 4 2019-06-19 0 0000831547 SPECTRUM PHARMACEUTICALS INC SPPI 0001474553 Ashton William 11500 S. EASTERN AVE., SUITE 240 HENDERSON NV 89052 1 0 0 0 Common Stock, $0.001 par value 2019-06-19 4 S 0 5000 8.59 D 8333 D Common Stock, $0.001 par value 2019-06-20 4 S 0 1667 8.50 D 6666 D Common Stock, $0.001 par value 2019-06-20 4 A 0 10000 0.00 A 16666 D Stock Option (Right to Buy) 8.44 2019-06-20 4 A 0 20000 0.00 A 2029-06-20 Common Stock 20000 20000 D All sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 18, 2019. 100% of the restricted shares shall vest on the earlier of (1) June 20, 2020 or (2) the date of the company's 2020 Annual Meeting of Stockholders. 25% of the option shares vested on June 20, 2019. The remaining option shares shall vest in 25% equal annual amounts on each anniversary date of the grant over three years. /s/ Kurt A. Gustafson, attorney-in-fact for William L. Ashton 2019-06-21