X0306 4 2020-03-20 0 0001649904 RHYTHM PHARMACEUTICALS, INC. RYTM 0001473930 Foley Todd C/O MPM ASSET MANAGEMENT 450 KENDALL STREET CAMBRIDGE MA 02142 1 0 0 0 Common Stock 2020-03-20 4 S 0 1100 15.00 D 2361763 I See Footnote The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Shares were sold as follows: 1,058 by BV V and 42 by AM BV5. The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.00 to $15.01. The Reporting Person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. Shares are held as follows: 2,273,457 by BV V and 88,306 by AM BV5. The Reporting Person disclaims beneficial ownership of the securities except to the extent of his pecuniary interest therein. /s/ Todd Foley 2020-03-24