X0303 4 2010-02-24 0 0001129425 ZYMOGENETICS INC ZGEN 0001472555 Miller Dennis M. C/O ZYMOGENETICS, INC. 1201 EASTLAKE AVENUE EAST SEATTLE WA 98102 0 1 0 0 Sr VP, Resrch & Preclin Devl Common Stock 2010-02-24 4 S 0 662 5.66 D 6099 D Represents shares withheld for payment of tax liability arising as a result of the partial settlement of a restricted stock unit award originally reported by the reporting person in a Form 3 filed with the Commission on 09/16/2009. /s/ Dennis M. Miller 2010-02-26