SCHEDULE 13G/A 0001104659-20-021228 0001472322 XXXXXXXX LIVE 8 Common Stock, $0.001 par value 03/31/2025 0001484565 SOLENO THERAPEUTICS, INC. 834203309 100 MARINE PARKWAY, SUITE 400 REDWOOD CITY CA 94065 Rule 13d-1(b) Nantahala Capital Management, LLC MA 0.00 2627651.00 0.00 2627651.00 2627651.00 N 5.6 IA Wilmot B. Harkey X1 0.00 2627651.00 0.00 2627651.00 2627651.00 N 5.6 IN Daniel Mack X1 0.00 2627651.00 0.00 2627651.00 2627651.00 N 5.6 IN SOLENO THERAPEUTICS, INC. 100 MARINE PARKWAY, SUITE 400 REDWOOD CITY, CA, 94065 (1) Nantahala Capital Management, LLC ("Nantahala") (2) Wilmot B. Harkey (3) Daniel Mack (together the "Reporting Persons") 130 Main St. 2nd Floor, New Canaan, CT 06840 (1) Nantahala is a Massachusetts limited liability company. (2) Each of Messrs. Harkey and Mack is a citizen of the United States of America. N IA HC As of 03-31-2025 Nantahala may be deemed to be the beneficial owner of 2,627,651 Shares held by funds and separately managed accounts under its control, and as the managing members of Nantahala, each of Messrs. Harkey and Mack may be deemed to be a beneficial owner of those Shares. 2,627,651 Shares includes 870,628 Shares which may be acquired by the Reporting Persons within sixty days through the exercise of warrants. As of 03-31-2025, each of the Reporting Persons may be deemed to be the beneficial owner of the following percentage of the total number of Shares outstanding based on 45,857,291 shares outstanding received from the issuer on FORM 10-K FEBRUARY 28, 2025. : (1) Nantahala Capital Management, LLC ("Nantahala") : 5.6% (2) Wilmot B. Harkey: 5.6% (3) Daniel Mack: 5.6% % (1) Nantahala Capital Management, LLC ("Nantahala") : 0 Shares. (2) Wilmot B. Harkey: 0 Shares. (3) Daniel Mack: 0 Shares. (1) Nantahala Capital Management, LLC ("Nantahala") : 2,627,651 Shares. (2) Wilmot B. Harkey: 2,627,651 Shares. (3) Daniel Mack: 2,627,651 Shares. (1) Nantahala Capital Management, LLC ("Nantahala") : 0 Shares. (2) Wilmot B. Harkey: 0 Shares. (3) Daniel Mack: 0 Shares. (1) Nantahala Capital Management, LLC ("Nantahala") : 2,627,651 Shares. (2) Wilmot B. Harkey: 2,627,651 Shares. (3) Daniel Mack: 2,627,651 Shares. Y Y N Each of Messrs. Harkey and Mack is filing this Schedule 13G as a control person in respect of shares beneficially owned by Nantahala, an investment adviser as described in ss. 240.13d-1(b)(1)(ii)(E). See Item 4(a). Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Nantahala Capital Management, LLC /s/ Taki Vasilakis 04/30/2025 Wilmot B. Harkey /s/ Wilmot B. Harkey 04/30/2025 Daniel Mack /s/ Daniel Mack 04/30/2025