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Stock-Based Compensation, Assumptions Used to Value Stock Options Granted (Details) - $ / shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Assumptions Used in Determining Fair Value of Stock Options Granted [Abstract]    
Volatility 100.53% 97.50%
Risk-free interest rate 0.49% 0.39%
Expected term 6 years 21 days 6 years 14 days
Dividend rate 0.00% 0.00%
Fair value of option on grant date (in dollars per share) $ 7.65 $ 1.14