Nature of Operations (Details) $ in Millions	12 Months Ended
	Dec. 31, 2021 USD ($) Patent ClinicalTrial	Mar. 01, 2022 Patent
Nature of Operations [Abstract]
Number of planned clinical trials delayed | ClinicalTrial	2
Number of planned clinical trials | ClinicalTrial	3
Ministry of Science, Technology and Innovation of Brazil [Member] | Clinical Development and Commercialization of COVID-19 Vaccine [Member]
Nature of Operations [Abstract]
Committed funding to COVID-19 vaccine consortium | $	$ 60
U.S. [Member]
Nature of Operations [Abstract]
Number of patents held	6
Number of pending patent applications	16
Foreign [Member]
Nature of Operations [Abstract]
Number of patents held		70
Foreign [Member] | Subsequent Event [Member]
Nature of Operations [Abstract]
Number of pending patent applications		38