Stock-Based Compensation, Stock Option Activity (Details) - USD ($)		12 Months Ended
	Mar. 13, 2019	Dec. 31, 2020	Dec. 31, 2019
Unamortized Stock Compensation Expense [Abstract]
Unamortized stock compensation expense		$ 1,317,615
Weighted-average grant date fair value, granted (in dollars per share)	$ 8.23	$ 1.14	$ 5.67
Stock Options [Member]
Number of Shares [Roll Forward]
Options outstanding, beginning balance (in shares)		1,421,797
Granted (in shares)		331,407
Exercised (in shares)		0
Forfeited (in shares)		(84,583)
Expired (in shares)		(17,724)
Options outstanding, ending balance (in shares)		1,650,897	1,421,797
Vested and expected to vest (in shares)		1,650,897
Exercisable (in shares)		1,090,493
Weighted Average Exercise Price [Roll Forward]
Options outstanding, beginning balance (in dollars per share)		$ 15.95
Granted (in dollars per share)		1.46
Exercised (in dollars per share)		0
Forfeited (in dollars per share)		41.19
Expired (in dollars per share)		4.69
Options outstanding, ending balance (in dollars per share)		11.87	$ 15.95
Vested and expected to vest (in dollars per share)		11.87
Exercisable (in dollars per share)		$ 16.29
Remaining Contractual Life and Aggregate Intrinsic Value [Abstract]
Options outstanding, weighted average remaining contractual life		7 years 11 days	6 years 11 months 26 days
Vested and expected to vest, weighted average contractual life		7 years 11 days
Exercisable, weighted average contractual life		5 years 5 months 19 days
Options outstanding, aggregate intrinsic value		$ 226,731
Vested and expected to vest, aggregate intrinsic value		226,731
Exercisable, aggregate intrinsic value		$ 0
Unamortized Stock Compensation Expense [Abstract]
Period for recognition		2 years 10 months 28 days
Weighted-average grant date fair value, granted (in dollars per share)		$ 1.14