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Stock Options, Assumptions Used to Value Stock Options and Warrants Granted (Details) - $ / shares
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Assumptions Used in Determining Fair Value of Stock Options and Warrants Granted [Abstract]    
Volatility 90.40% 89.37%
Risk-free interest rate 2.34% 1.90%
Expected term 6 years 1 month 10 days 6 years 18 days
Dividend rate 0.00% 0.00%
Fair value of option on grant date (in dollars per share) $ 10.88 $ 6.67