Number of equity-based compensation plans.

No definition available.

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- Definition

Refers to the percentage of stock outstanding as of the immediately preceding December 31st used to determine the annual increase in the Plan limit for authorized shares that may be granted as qualified and nonqualified options.

+ References

No definition available.

+ Details

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- Definition

Refers to the percentage of the total combined voting power of all classes of stock owned, directly or indirectly, by an option holder at the time an incentive stock option is granted.

+ References

No definition available.

+ Details

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- Definition

Refers to the number of equal monthly installments awarded options will vest.

+ References

No definition available.

+ Details

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- Definition

Term the Plan shall continue to remain effective, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

No definition available.

+ Details

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- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 14.F)
-URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

+ Details

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Balance Type:	debit
Period Type:	duration

- References

No definition available.

+ Details

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- References

No definition available.

+ Details

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- Definition

Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

+ Details

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Period Type:	duration

- References

No definition available.

+ Details

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- Definition

The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

+ References

+ Details

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- Definition

The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

+ References

+ Details

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- Definition

The risk-free interest rate assumption that is used in valuing an option on its own shares.

+ References

+ Details

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- Definition

The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested).

+ References

+ Details

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Data Type:	xbrli:sharesItemType
Balance Type:	na
Period Type:	instant

- Definition

Gross number of share options (or share units) granted during the period.

+ References

No definition available.

+ Details

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Balance Type:	na
Period Type:	duration

- Definition

The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

+ References

+ Details

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Period Type:	duration

- Definition

Percentage of vesting of share-based compensation awards.

+ References

+ Details

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- Definition

Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

+ Details

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Period Type:	duration

- Definition

Expected term of share-based compensation awards, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(i)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 14.D.2)
-URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809

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- Details

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- Details

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- Details

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- Details

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Stock Options, Equity Compensation Plans (Details)		3 Months Ended		6 Months Ended		12 Months Ended
Stock Options, Equity Compensation Plans (Details)	Nov. 16, 2015 shares	Jun. 30, 2016 USD ($) Plan $ / shares	Jun. 30, 2015 USD ($) $ / shares	Jun. 30, 2016 USD ($) Plan Installment $ / shares shares	Jun. 30, 2015 USD ($) $ / shares	Dec. 31, 2014 shares	Jan. 02, 2016 shares	Jan. 02, 2015 shares	Dec. 31, 2013 shares	Dec. 31, 2012 shares	Dec. 31, 2010 shares
Stock Options [Abstract]
Number of equity compensation plans \| Plan		3		3
Stock-Based Compensation [Abstract]
Stock-based compensation expense \| $		$ 1,380,994	$ 583,515	$ 2,796,296	$ 954,684
Assumptions Used in Determining Fair Value of Stock Options and Warrants Granted [Abstract]
Volatility		71.80%	79.80%	78.50%	79.80%
Risk-free interest rate		1.29%	1.58%	1.39%	1.79%
Expected term		5 years 8 months 5 days	6 years 29 days	6 years 4 days	6 years 25 days
Dividend rate		0.00%	0.00%	0.00%	0.00%
Fair value of option on grant date (in dollars per share) \| $ / shares		$ 5.81	$ 4.39	$ 5.11	$ 4.28
W. Bradford Middlekauff [Member] \| Nonqualified Options [Member]
Stock Options [Abstract]
Options granted (in shares)	80,000
Vesting period				4 years
W. Bradford Middlekauff [Member] \| Nonqualified Options [Member] \| Vesting on October 30, 2016, One Year Following Date of Hire [Member]
Stock Options [Abstract]
Vesting percentage				25.00%
W. Bradford Middlekauff [Member] \| Nonqualified Options [Member] \| Vesting in 36 Monthly Installments Thereafter [Member]
Stock Options [Abstract]
Vesting percentage				75.00%
Number of monthly installments for vesting \| Installment				36
The Plans [Member] \| Stock Options [Member]
Stock Options [Abstract]
Options granted (in shares)				976,400
The Plans [Member] \| Incentive Stock Options [Member]
Stock Options [Abstract]
Vesting period				4 years
Percentage of total combined voting power of all classes of stock held by an option holder				10.00%
The Plans [Member] \| Incentive Stock Options [Member] \| Minimum [Member]
Stock Options [Abstract]
Term of option				5 years
The Plans [Member] \| Incentive Stock Options [Member] \| Maximum [Member]
Stock Options [Abstract]
Term of option				10 years
The Plans [Member] \| Nonqualified Options [Member] \| Minimum [Member]
Stock Options [Abstract]
Vesting period				3 years
The Plans [Member] \| Nonqualified Options [Member] \| Maximum [Member]
Stock Options [Abstract]
Vesting period				4 years
2010 Equity Incentive Plan [Member]
Stock Options [Abstract]
Number of shares authorized for issuance (in shares)						1,350,412			1,279,146		548,206
Term of plan				10 years
2012 Equity Incentive Plan [Member]
Stock Options [Abstract]
Number of shares authorized for issuance (in shares)										1,096,411
Term of plan				10 years
2014 Equity Incentive Plan [Member]
Stock Options [Abstract]
Number of shares authorized for issuance (in shares)						1,827,351	3,047,323	1,894,890
Percentage of Common Stock outstanding used to determine annual increase in the Plan Limit						4.00%
Options granted (in shares)						0
Term of plan				10 years
Research and Development [Member]
Stock-Based Compensation [Abstract]
Stock-based compensation expense \| $		$ 544,702	$ 265,029	$ 1,042,232	$ 428,541
General and Administrative [Member]
Stock-Based Compensation [Abstract]
Stock-based compensation expense \| $		$ 836,292	$ 318,486	$ 1,754,064	$ 526,143