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Statements of Cash Flows - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Cash flows from operating activities:      
Net loss $ (28,078,646) $ (12,201,386) $ (6,883,080)
Adjustments to reconcile net loss to net cash used in operating activities:      
Stock-based compensation expense 2,899,304 1,297,985 260,361
Warrant remeasurement 1,879,823 (582,360) 854,336
Depreciation expense 53,116 31,229 4,444
Amortization of debt discount 104,311 35,288 0
Amortization of debt issuance costs 94,648 0 0
Non-cash interest expense 38,521 6,384 0
Changes in assets and liabilities:      
Other receivable 0 459,018 (459,018)
Prepaid expenses and other assets (814,156) (96,754) (261,332)
Accounts payable (71,751) 526,869 (1,661,421)
Accrued expenses 2,142,187 808,514 100,817
Net cash used in operating activities (21,752,643) (9,715,213) (8,044,893)
Cash flows from investing activities:      
Purchases of property and equipment (1,305,086) (884,793) (136,894)
Net cash used in investing activities (1,305,086) (884,793) (136,894)
Cash flows from financing activities:      
Proceeds from convertible note payable 0 0 100,000
Proceeds from issuance of debt 3,000,000 3,000,000 0
Proceeds from exercise of stock options 1,094 0 0
Payments for issuance costs (1,402,845) (1,351,450) 0
Payments for debt issuance costs 0 (94,998) 0
Payments for debt payable (533,729) 0 0
Payments on note payable to stockholders 0 0 (22,052)
Proceeds from issuance of common stock, net of underwriting costs 86,059,087 0 0
Proceeds from issuance of preferred stock, net of issuance costs 52,394,571 14,917,257 15,821,075
Net cash provided by financing activities 139,518,178 16,470,809 15,899,023
Net increase in cash 116,460,449 5,870,803 7,717,236
Cash and cash equivalents at beginning of period 13,728,972 7,858,169  
Cash and cash equivalents at end of period 130,189,421 13,728,972 7,858,169
Cash paid for:      
Interest 559,175 82,729 94
Income taxes 0 0 1,759
Supplemental cash flow information:      
Conversion of Preferred Stock to Common Stock 93,364,275 0 0
Conversion of Preferred Stock Warrants to Common Stock Warrants 3,726,043 0 0
Conversion of notes payable and accrued interest to preferred stock 0 0 253,365
Deferred issuance costs included in accrued expenses and accounts payable 549,178 53,946 0
Non-cash financing costs 175,114 0 0
Accrued capital expenditures included in accrued expenses $ 71,040 $ 450,373 $ 0