X0306 4/A 2016-08-09 2016-08-09 0001472091 Edge Therapeutics, Inc. EDGE 0001214501 MIDDLEKAUFF W BRADFORD 300 CONNELL DRIVE SUITE 4000 BERKELEY HEIGHTS NJ 07922 1 Senior VP, GC and Secretary Common Stock 12850.96 I 401(K) Plan Reflects periodic contributions to the issuer's common stock fund in the issuer's 401(K) Plan as of December 28, 2018. This amendment is being filed to include these shares of the issuer's common stock that were omitted in the prior report. /s/ W. Bradford Middlekauff, Reporting Person 2018-12-31