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Share-based compensation - Plans (Details) - $ / shares
3 Months Ended
Jan. 01, 2025
Oct. 02, 2023
Jun. 28, 2023
Mar. 31, 2025
Dec. 31, 2024
Oct. 31, 2024
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Shares available for future issuance       18,495,387 15,528,401  
Options, Granted       224,000    
Granted       $ 10.10    
Dr. Clay Siegall | Morphimmune Inc            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Options, Granted     2,137,080      
Granted     $ 5.91      
Dr. Clay Siegall | Morphimmune Inc | One-year anniversary            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Percentage of vesting   25.00%        
Vesting period   1 year        
Dr. Clay Siegall | Morphimmune Inc | Over next 36 months            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Percentage of vesting   75.00%        
Vesting period   36 months        
2020 Plan            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Shares available for future issuance       4,475,485    
Increase in shares available for future issuance 2,578,433          
2024 Inducement Plan            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Shares available for future issuance           2,000,000
Shares available for grant       414,300    
MorphImmune Plan            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Shares available for future issuance       555,895    
2020 Employee Stock Purchase Plan            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Increase in shares available for future issuance 664,608          
Shares available for grant       1,550,859 906,251  
Awards granted       0