Strategic transactions and agreements - Zentalis Pharmaceuticals (Details) - USD ($) $ / shares in Units, $ in Thousands			3 Months Ended
	Oct. 25, 2024	Jan. 05, 2024	Mar. 31, 2025	Mar. 31, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Issuance of common stock			$ 161,745	$ 215,410
Zentalis Asset Purchase Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Issuance of common stock				$ 23,388
Number of shares issued	1,805,502
Common stock issued	$ 21,000
Share Price	$ 12.11
Percentage of discount related to unregistered share restrictions to be deducted from the share price	4.00%
Cash upon the achievement of a developmental milestone	$ 5,000
License agreement with Zentalis Pharmaceuticals, Inc
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License Agreement, Upfront Payment in Cash		$ 15,000
Shares issued		2,298,586
Issuance of common stock		$ 23,400
Share Price		$ 11.12
Percentage of discount related to unregistered share restrictions to be deducted from the share price		8.50%
Transaction cost		$ 200