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Income taxes - Federal income tax (Details)
12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Income taxes    
Federal tax benefit at statutory rate 21.00% 21.00%
State tax, net of federal benefit 0.50% (1.30%)
Research and development credits 2.10% 0.70%
Share-based compensation (0.70%) (0.90%)
Write-off of IPR&D   (15.90%)
Change in valuation allowance (22.80%) (3.60%)
Other (0.10%)