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Share-based compensation - Plans (Details) - $ / shares				1 Months Ended		12 Months Ended
Share-based compensation - Plans (Details) - $ / shares	Jan. 01, 2025	Oct. 02, 2023	Jun. 28, 2023	Sep. 30, 2020	Aug. 31, 2020	Dec. 31, 2024	Oct. 31, 2024	Dec. 31, 2023
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for future issuance						15,528,401		13,202,327
Options, Granted						6,616,169
Granted						$ 14.66
Dr. Clay Siegall \| Morphimmune Inc
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options, Granted			2,137,080
Granted			$ 5.91
Dr. Clay Siegall \| Morphimmune Inc \| One-year anniversary
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of vesting		25.00%
Dr. Clay Siegall \| Morphimmune Inc \| Over next 36 months
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of vesting		75.00%
Vesting period		36 months
2020 Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Threshold Percentage Of Total Number Of Common Stock Outstanding					4.00%
Shares available for future issuance						1,698,331
Expiration period						10 years
2020 Plan \| Subsequent events
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Increase in shares available for future issuance	2,578,433
2020 Plan \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period						4 years
2020 Plan \| Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period						1 year
2024 Inducement Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for future issuance							2,000,000
Shares available for grant						559,300
MorphImmune Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for future issuance		373,738
Employee Stock Purchase Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Authorized stock options						125,000
Employee Stock Purchase Plan, Threshold Period For Which Common Stock Is Automatically Added To Arrive At Authorized Shares						10 years
Percentage of outstanding capital stock						1.00%
Purchase price percentage				85.00%
Maximum number of shares that can be purchased				15.00%
Number of common shares added in authorized						1,000,000
Shares available for grant						906,251		473,733
Awards granted						0
Employee Stock Purchase Plan \| Subsequent events
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Increase in shares available for future issuance	644,608