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Income taxes - Federal income tax (Details)
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Income taxes    
Federal tax benefit at statutory rate 21.00% 21.00%
State tax, net of federal benefit (1.30%) 4.30%
Effects of state tax legislation, net of federal benefit   (7.10%)
Research and development credits 0.70% 1.90%
Permanent differences (0.90%) (0.20%)
Write-off of IPR&D (15.90%)  
Change in valuation allowance (3.60%) (19.90%)
Total