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Share-based compensation - Plans (Details) - USD ($) $ / shares in Units, $ in Millions						12 Months Ended
	Jan. 01, 2024	Oct. 02, 2023	Sep. 29, 2023	Jan. 01, 2023	Sep. 18, 2020	Dec. 31, 2023	Dec. 31, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expiration period						10 years
Options, Granted						4,007,552
Weighted average grant date fair value						$ 6.09	$ 2.65
Morphimmune Inc
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise price		$ 1.29
Dr. Clay Siegall \| Morphimmune Inc
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options, Granted						2,137,080
Exercise price						$ 5.91
Estimated grant date fair value		$ 14.2
Weighted average grant date fair value		$ 6.65
Dr. Clay Siegall \| Morphimmune Inc \| One-year anniversary
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of vesting		25.00%
Dr. Clay Siegall \| Morphimmune Inc \| Over next 36 months
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period		36 months
Percentage of vesting		75.00%
Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period						4 years
Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period						1 year
2020 Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Threshold Percentage Of Total Number Of Common Stock Outstanding					4.00%
Shares available for future issuance						3,320,601
Increase in shares available for future issuance			2,955,280	485,153
2020 Plan \| Subsequent Event [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Increase in shares available for future issuance	1,730,071
MorphImmune Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for future issuance		929,702
Employee Stock Purchase Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for grant						473,733
Increase in shares available for future issuance				121,288
Authorized stock options						125,000
Employee Stock Purchase Plan, Threshold Period For Which Common Stock Is Automatically Added To Arrive At Authorized Shares						10 years
Percentage of outstanding capital stock						1.00%
Number of common shares added in authorized						1,000,000
Awards granted						0
Employee Stock Purchase Plan \| Subsequent Event [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Increase in shares available for future issuance	432,518