Share-based compensation (Tables)

12 Months Ended

Dec. 31, 2023

Share-based compensation

Schedule of stock-based compensation expense

Share-based compensation expense recorded as research and development and general and administrative expenses in the consolidated statements of operations and comprehensive loss is as follows (in thousands):

	Year Ended December 31,
In thousands)	2023		2022
General and administrative	$	4,242	$	3,471
Research and development		1,981		1,861
	$	6,223	$	5,332

Schedule of weighted average assumptions used in option-pricing

	Year ended December 31,
	2023			2022
Expected volatility		92.1	%		85.6	%
Risk-free interest rate		4.6	%		2.7	%
Expected term (in years)		5.6			6.0
Expected dividend yield		—			—
Fair value of common stock	$	7.92		$	3.63

Schedule of option activity

				Weighted
		Weighted		average
		average		remaining
	Number of	exercise price		contractual
	shares	per share		term (years)
Outstanding at January 1, 2023	2,519,405		9.60
Replacement options issued at asset acquisition	2,472,563		1.29
Granted	4,007,552		6.42
Forfeited	(314,319)		6.67
Expired	(55,670)		16.59
Exercised	(651,240)		1.57
Outstanding at December 31, 2023	7,978,291		6.15	8.62
Exercisable at December 31, 2023	3,151,799		5.86	7.54