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Share-based compensation - Option Activity and Restricted Stock (Details) - USD ($)
$ / shares in Units, $ in Millions
9 Months Ended 12 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Dec. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]      
Options, Beginning balance 2,005,756    
Options, Granted 543,900    
Options, Forfeited (22,042)    
Options, Expired (634)    
Options, Exercised (17,221)    
Options, Ending balance 2,509,759   2,005,756
Options, Exercisable 1,111,573    
Weighted Average Exercise price      
Beginning price $ 11.26    
Granted 3.64    
Forfeited 12.20    
Expired 17.96    
Exercised 1.85    
Ending price 9.66   $ 11.26
Exercisable $ 8.41    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]      
Weighted Average Remaining Contractual Term 8 years 1 month 13 days   8 years 6 months
Weighted Average Remaining Contractual Term, Granted 9 years 5 months 12 days    
Weighted Average Remaining Contractual Term, Exercised 7 years 4 months 2 days    
Weighted Average Remaining Contractual Term, Exercisable 7 years 4 months 28 days    
Weighted average grant date fair value $ 2.65 $ 17.77  
Intrinsic value, exercised $ 0.1    
Intrinsic value, outstanding $ 3.4