Balance sheet components - Accrued expenses and other current liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Balance sheet components
Compensation and related benefits	$ 11,527	$ 5,861
Development milestones	10,000	6,150
Manufacturing expenses	9,462	6,544
Clinical development expenses	$ 7,036	$ 6,581
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]	Total accrued expenses and other current liabilities	Total accrued expenses and other current liabilities
Operating lease liabilities, current portion	$ 0	$ 63
Other	3,626	7,978
Total accrued expenses and other current liabilities	$ 41,651	$ 33,177