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Nature of the business (Details) - USD ($)
$ in Thousands
Sep. 30, 2025
Dec. 31, 2024
Sep. 30, 2024
Nature of the business      
Accumulated deficit $ 658,264 $ 515,770  
Non-restricted cash and cash equivalents 272,639 143,351 $ 155,568
Marketable securities $ 0 $ 73,952