| Harnessing the Power of the Human Memory B Cell JANUARY 2023 Immunome, Inc. 665 Stockton Drive, Suite 300 | Exton, PA 19341 610.321.3700 | immunome.com Copyright © 2023 Immunome, Inc. All rights reserved. |
| 2 Disclaimers and Forward - Looking Statements Copyright © 2023 Immunome, Inc. All rights reserved. This presentation includes certain disclosures that contain “forward - looking statements” intended to qualify for the “safe harbor” from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding our beliefs and expectations regarding the advancement of our oncology and infectious disease programs and platform, execution of our regulatory, clinical and strategic plans, therapeutic potential and benefits of our programs and anticipated upcoming milestones for our programs, as well as the timing and progress of each of the foregoing matters. Forward - looking statements may be identified by the words “anticipate,” believe,” “estimate,” “expect,” “intend,” “plan,” “project,” “suggest,” “may,” “will,” “could,” “should,” “seek,” “potential” and similar expressions. Forward - looking statements are based on our current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, the following: our ability to execute on our strategy, including with respect to R&D efforts, IND submissions and other regulatory filings, timing of these filings and the timing and nature of governmental authority feedback regarding the same, initiation and completion of any clinical studies, confirmatory testing and other anticipated milestones as and when anticipated; the fact that research and development data are subject to differing interpretations and assessments, including during the peer review/publication process in the scientific community and by regulatory authorities; whether our data will be published in a scientific journal and, if so, when and with what modifications; the effectiveness of our product candidates, including the possibility that further preclinical data and any clinical trial data may be inconsistent with earlier - published data and/or data used for advancing the product candidates; the fact that changes in the profile of the diseases that our programs target could emerge that could impact our ability to address those changes; our ability to fund operations; our reliance on vendors; our ability to execute on our plans for collaborations and partnerships; the competitive landscape; the impact of the COVID - 19 pandemic on our business, operations, strategy, goals and anticipated milestones; and the additional risks and uncertainties set forth more fully under the caption “Risk Factors” in Immunome’s Annual Report on Form 10 - K filed with the United States Securities and Exchange Commission (SEC) on March 28, 2022, and elsewhere in Immunome’s Quarterly Reports on form 10 - Q and other filings and reports with the SEC. All statements contained in this presentation are made as of the date specified on the cover, and we undertake no duty to publicly update or revise any such statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law. This presentation may contain product names, trade names, trademarks and service marks of Immunome and of other organizations, which are the properties of their respective owners. Statements that “we believe” and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based on information available to us as of the date of this presentation, including independent market research, industry publications and surveys, governmental agency publications and other publicly available information. While we believe that information provides a reasonable basis for these statements, it may be limited or incomplete and we may have not independently verified it. Our statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review or verification of, all relevant information. We make statements and predictions about future dates for achievement of milestones related to our platform and our programs in this presentation. These statements and predictions involve risks and uncertainties based on various factors and evolution over time and, therefore, actual dates for these milestones may differ. In this presentation and oral commentary, we may discuss our current and potential future product candidates that have not yet undergone clinical trials or been approved for marketing by the U.S. Food and Drug Administration or other governmental authority. No representation is made as to the safety or effectiveness of these current or potential future product candidates for the use for which such product candidates are being studied. This presentation does not constitute an offering of securities of any kind. |
| Powered by Human Memory B Cell Interrogation 3 Immunome: Three - Pronged Strategy Copyright © 2023 Immunome, Inc. All rights reserved. Successfully execute on AbbVie collaboration → $30M upfront → Eligible for up to: – $70M platform access payments – Per target option payments (low single digit millions) – $2.7B downstream economics – Tiered royalties Extract value from the breadth of Immunome’s Discovery Engine → Platform and asset - based partnerships → Novel oncology target/antibody pairs – Includes ADC, TCE modalities Advance proprietary oncology pipeline → IMM - ONC - 01 (targeting IL - 38) IND submission by mid - 2023 → Research pipeline 03 02 01 Cash runway at least through 3Q 2024 |
| 4 Strategic Discovery Collaboration with AbbVie Copyright © 2023 Immunome, Inc. All rights reserved. → AbbVie option to purchase worldwide rights for up to 10 novel target - antibody pairs arising from three specified tumor types → Key Financial Terms – $30M upfront payment – Eligible for additional payments up to: • $70M platform access payments (in addition to potential per target option payments – low single digit millions ) • $120M per target development and first commercial sale milestones • $150M per target further sales - based milestones • Tiered royalties on global sales This collaboration with AbbVie, a true leader in the development and commercialization of oncology therapeutics, demonstrates the strength of Immunome’s Discovery Engine. PURNANAND SARMA President & CEO, Immunome Immunome’s approach has the potential to unlock novel cancer biology and yield multiple therapeutic candidates. STEVE DAVIDSEN VP, Oncology Discovery Research, AbbVie |
| We See the Disease Through the Lens of a Memory B Cell Interrogate Most Educated Components of Immune Response in an Unbiased Manner at Industrial Scale 5 Copyright © 2023 Immunome, Inc. All rights reserved. Patient Ab responses point to actionable public targets 2 03 Patient responses unveil novel disease targets Proprietary Discovery Engine interrogates function of patient memory B cell responses 02 Patients’ immune responses recognize and respond to disease in clinically important ways 1 01 Immune Modulation Novel Targets Discovery Engine Extracellular Matrix 1. Nature 577 :549 - 555, 556 - 560, & 561 - 65 (2020) 2. Immunome internal data Cataloging the Context - Dependent B Cell Response Against Cancer We See the Disease Through the Lens of a Memory B Cell Broad Applicability Across Therapeutic Areas |
| Broad Applicability Across Therapeutic Areas Unbiased Interrogation Unveils Targets & Underexplored Biology: Examples 6 Copyright © 2023 Immunome, Inc. All rights reserved. Immunology: Conserved Epitopes Identification of antibodies specific for broadly conserved epitopes, including across species Infectious Disease: Multi - modal Action Unique insights into breadth of immune response against SARS - CoV - 2 by super responder patients Oncology: Target Rich Clusters Targets identified across patients with different tumors cluster around distinct areas of tumor biology Immune Modulation Novel Targets Discovery Engine Extracellular Matrix DiMuzio et al VaccineX 2021 Need a figure for this panel Knowles et al Nature Reviews Molecular Cell Biology (2014) https:// doi.org /10.1038/nrm3810 |
| 7 Platform has Potential for Partnering Across Therapeutic Areas Copyright © 2023 Immunome, Inc. All rights reserved. → $30M Upfront → $70M Platform Milestones → Low single digit millions options payments per target → $120M/target Development and First Commercial Sale Milestones → $150M/target Sales based Milestones → Tiered Royalties on Global Sales IMM - BCP - 01 (SARS - CoV - 2 Antibody Cocktail) Anti - Infectives 01 Oncology Solid Tumors 02 03 04 05 → $17.6M non - dilutive funding (OTA: W911Q - Y - 20 - 9 - 0019) → Funded by U.S. DoD JPEO - CBRND in collaboration with DHA → Various Malignancies Oncology, Hematology → Auto - Immune Disorders → Immunology Immune Disorders → Neuroinflammation Neurology Up to 10 novel antibody - target pairs in 3 tumor types Potential Future Therapeutic Areas |
| Immunome Pipeline Targets Identified from Authentic Human Immune Response 8 Copyright © 2023 Immunome, Inc. All rights reserved. PROGRAM POTENTIAL DISEASE OF RELEVANCE STAGE NEXT MILESTONE IMM - ONC - 01 (Anti - IL - 38) Soluble Cytokine, Immune Modulator Neutralize IL - 38; recruit and activate immune cells Squamous carcinomas of head & neck, gastroesophageal, lung Preclinical Development IND submission mid - 2023 IMM20059 (Anti - EPN1) Membrane Dynamics Ectopically expressed on cancer cells and exosomes; modulate receptor trafficking; reactivate exhausted anti - tumor T cells Melanoma, breast, lung, bladder, genitourinary, and liver cancers Target Research & Lead ID Lead nomination Undisclosed oncology targets Suitable for ADC and T Cell Engager Modalities Solid tumors Target Research & Lead ID Lead nomination IMM - BCP - 01 (Anti SARS - CoV - 2)* Three antibody cocktail (multi - modal action, including neutralization and complement activation) COVID - 19 Phase 1b* Actively exploring partnerships OTHER ONCOLOGY • We completed dosing of the first cohort of patients with no significant treatment - related adverse events. We have decided to see k a partner in order to continue the trial and for any further development activities. |
| ONCOLOGY Platform and Pipeline Copyright © 2023 Immunome, Inc. All rights reserved. |
| B cells: Critical Players in Immunity Oncology 10 Copyright © 2023 Immunome, Inc. All rights reserved. → B cell infiltration more closely associated with survival than T cell presence in multiple cancers → Success of I/O therapies appears to be associated with coordinated response including B cells and TLS in the unique context of each patient’s tumor microenvironment → However, specificity of the B cell immune repertoire has not been explored beyond known tumor antigens Cabrita et al, Nature (2020) Survival in Melanoma Patients |
| Immunome’s Discovery Engine Functional B Cell Interrogation to Actionable Public Targets 11 Copyright © 2023 Immunome, Inc. All rights reserved. Functional screening prioritizes patient - derived antibodies that bind to actionable public targets 0 .. 0 1 0 .. 1 1 1 0 1 0 0 0 20 40 60 80 100 Log Conc. (nM) % C y t o t o x i c i t y Antibody B -Vc-MMAF anti-RSV -Vc-MMAF Unconj. Vc-MMAF Cetuximab-Vc-MMAF Tr a s t u z u m a b ( H e r 2 ) 03 Memory B Cells Represent One of the Most Educated Components of the Human Immune System Discovery Engine interrogates patient memory B cell responses in unbiased manner and at industrial scale 02 Tumor Types B cells identify important targets within the natural context of disease 01 Pero et al, Clin Trans Immunol (2022) Autologous Tumor binding Immunome Internal Data |
| Unveiling “Tumor Context” Novel Insights Into Tumor Targets and Biological Processes 12 Copyright © 2023 Immunome, Inc. All rights reserved. Immune Modulation Novel Targets Discovery Engine Extracellular Matrix Platform identifies both validated and novel actionable cancer targets Identifies targets with expression linked to clinical outcomes (IMM - ONC - 01 targeting IL - 38) Discovery Engine highlights unique features of cancer cells → Unexpected localization of proteins ( ectopic expression ) on tumor surface ~250K HYBRIDOMAS >70 ANTIBODY / TARGET PAIR 14 CANCERS >350 PATIENTS Diverse Cancer Landscape Antibody responses across diverse cancers highlight common areas of target - rich biology |
| Ectopic Expression: A Unique Class of Targets with Potentially High Tumor Selectivity High Throughput Identification of Antibody - Target Pairs for Novel Modalities 13 Copyright © 2023 Immunome, Inc. All rights reserved. Highly Productive Discovery Engine for ADC and TCE Targets High Throughput Functional Characterization: Example of a Typical Cascade Strong binding to tumor No binding to normal Internalization 5 T Cell Engager (TCE) mAbs (16%) Binds tumor cells Does not bind normal cells No internalization 5 ADC mAbs (16%) Binds tumor cells Does not bind normal cells Efficient internalization 32 Antibodies Ectopic Expression Ectopically Expressed Targets: Some proteins normally found intracellularly appear to be selectively expressed on surface of tumor cells 02 01 |
| Example of an Ectopically Expressed Target as an ADC 14 Copyright © 2023 Immunome, Inc. All rights reserved. *Immunome internal data 0 1 0 0 0 2 0 0 0 3 0 0 0 4 0 0 0 0 10 20 30 40 Raw Binding Signal S - S c o r e 17. PR121-00372 C1 1orf68 Target B Ab Highly Selective for Single Protein Target Selective Tumor Cell Binding High Tumor:Normal Cell Binding Ratio Tumor Normal 0 .. 0 1 0 .. 1 1 1 0 1 0 0 0 20 40 60 80 100 Log Conc. (nM) % C y t o t o x i c i t y Anti-C1 1orf68-VC-MMAF Cetuximab-VC-MMAF Tr a s t u z u m a b - V C - M M A F anti-RSV -VC-MMAF free MMAF 0 .. 0 1 0 .. 1 1 1 0 1 0 0 0 20 40 60 80 100 Log Conc. (nM) % C y t o t o x i c i t y Antibody B -Vc-MMAF anti-RSV -Vc-MMAF Unconj. Vc-MMAF Cetuximab-Vc-MMAF Tr a s t u z u m a b ( H e r 2 ) Free MMAF Anti - RSV - VC - MMAF Antibody B - VC - MMAF Cetuximab (EGFR) - VC - MMAF Trastuzumab (Her2) - VC - MMAF Internalization Patient - derived Ab Suitable for ADC Format 0 6 12 18 24 0.0 5 .. 0 × 1 0 4 1 .. 0 × 1 0 5 1 .. 5 × 1 0 5 Ti m e ( h ) R e d t o t a l i n t e g r a t e d i n t e n s i t y / P h a s e A r e a Anti-C1 1orf68 a-RSV Neg Cntrl Antibody B 01 |
| Recent Clinical Success and Approvals Fueling Significant Investment in the ADC Space ADC Market: New Targets and Technologies Likely to Accelerate Growth Significant Number Of Recent ADC Approvals 15 Copyright © 2023 Immunome, Inc. All rights reserved. 1. The Antibody Society. Therapeutic monoclonal antibodies approved or in regulatory review. January 14, 2023; www.antibodysociety.org/antibody - therapeutics - product - data .. | 2. www.cortellis.com | 3. www.clinicaltrials.gov Robust Deal Activity in Linker/Payload Technologies → 2020 - 2023 → >10 deals in the range $400M - $2.6B 2 Clinical Landscape 2,3 → >10 active Late Clinical Programs 2 → >130 active Early Clinical Programs 2 → >250 ongoing clinical studies 3 4. Image adapted from: Fu, Z., Li, S., Han, S. et al. Antibody drug conjugate: the “biological missile” for targeted cancer ther apy. Sig Transduct Target Ther 7, 93 (2022). https://doi.org/10.1038/s41392 - 022 - 00947 - 7 4 1 |
| 16 Novel Targets Could Drive Future ADC Market Growth Copyright © 2023 Immunome, Inc. All rights reserved. Differentiated IMNM Platform → High throughput identification of novel targets → Ectopically expressed Commercial/Phase 3 Solid Tumor ADC Programs are Still Mostly Directed at a Limited Number of Known Targets 1,2 TOMORROW TODAY TROP2 FolR1 HER2 cMet Nectin4 CECAM5 ROR1 NaPi2b HER3 TF 1. The Antibody Society. Therapeutic monoclonal antibodies approved or in regulatory review. January 14, 2023; www.antibodysociety.org/antibody - therapeutics - product - data .. | 2. The Antibody Society. Antibody therapeutics in late - stage clinical studies. January 14, 2023; www.antibodysociety.org/antibodies - in - late - stage - clinical - studies/ |
| Substantial and Sustained Early - Stage ADC Partnering Activity 17 Copyright © 2023 Immunome, Inc. All rights reserved. → New ADC platforms are improving clinical outcomes of ADC products, leading to several recent approvals → Large recent investments in ADC platforms expected to increase the demand for novel targets → Ectopically expressed targets represent a unique ADC target class Merck - Kelun Preclinical (7 ADCs) Up to ~$9.5B 2022 Seagen - RemeGen Phase 2 Up to ~$2.6B 2021 BMS - Eisai Phase 1 Up to $3.1B 2021 Merck - Velos Phase 1/2 $2.8B 2020 AZN - Daiichi Sankyo Phase 1 Up to $6B 2020 BI - NBE Phase 1 $1.5B 2020 Preclinical Stage Deals 1 GSK - Mersana Preclinical Up to ~$1.3B 2022 1. www.cortellis.com |
| Oncology Lead Program IMM - ONC - 01 Copyright © 2023 Immunome, Inc. All rights reserved. |
| Anti - IL - 38 in Oncology Selective Immuno - oncology Therapy, IND Filing Anticipated Mid - 2023 19 Copyright © 2023 Immunome, Inc. All rights reserved. CPIs effective, but response rate is limited Cytokine - targeted therapies limited by inappropriate TME context, off - target effects, poor efficacy Anti - IL - 38 therapy may overcome several limitations → IL - 38 primarily expressed in epithelial tissues, frequent tumor source (carcinomas, adenomas) → IL - 38 effects are context - dependent, based upon cell pathology and inflammatory status → Anti - IL - 38 reactivates key immune antitumor pathways Potential indications include squamous cell carcinomas, such as head & neck, gastroesophageal and lung IgG1 IL - 38 neutralizing antibody expected to: → Promote activated immunocyte tumor infiltration → Enhance innate and adaptive immune antitumor response → Extend treatment response from hours to weeks → Benefit a significant proportion of patients treated |
| IL - 38 is Expressed in Multiple Tumors 2 IHC Data Supports Transcriptional Data 3 → Tumor Versus Healthy Adjacent Tissue Expression (% of Patient Expression) → Pathology Scoring of Individual Head & Neck Cancer Patient Samples by Stage IL - 38 Expression in Solid Tumors 20 Copyright © 2023 Immunome, Inc. All rights reserved. D o c 0 3 1 4 4 4 R n s 0 5 0 2 6 8 D o c 1 8 0 3 7 0 D o c 1 6 0 1 1 8 D o c 1 7 0 3 0 8 R l a 1 5 0 0 7 6 R l a 0 6 0 0 7 7 R l a 0 2 0 0 5 4 R l a 0 9 0 0 3 7 R l a 1 1 0 0 2 6 R l a 1 3 0 0 4 2 R l a 1 3 0 0 3 0 R l a 1 4 0 0 6 5 R l a 0 1 0 0 8 8 D o c 0 9 0 2 4 7 D o c 0 6 2 3 0 2 D o c 0 6 2 2 3 8 D o c 0 6 2 3 0 7 D o c 0 3 0 4 6 3 D o c 1 3 0 4 7 2 D o c 1 3 0 4 9 8 D o c 1 1 0 1 9 3 D o c 0 2 2 7 8 2 D o c 1 4 0 0 7 3 D o c 1 4 0 1 4 8 D o c 0 6 2 3 0 5 D o c 0 9 0 1 4 9 D o c 0 7 0 3 6 9 D o c 1 4 0 0 4 5 D o c 1 0 0 3 0 8 D o c 1 8 0 0 7 4 R l a 0 1 0 1 6 2 R l a 1 3 0 0 5 8 R l a 0 1 0 1 7 3 R l a 1 3 0 0 6 5 R l a 0 2 0 0 6 3 R l a 0 5 0 0 0 7 R l a 0 2 0 0 5 8 D o c 0 6 1 8 3 0 D o c 0 6 0 6 2 1 R n s 0 2 0 6 6 6 D o c 1 4 0 1 8 5 D o c 0 3 1 8 0 8 D o c 0 7 0 3 1 0 D o c 1 4 0 0 5 2 D o c 1 8 0 3 6 5 D o c 1 6 0 0 7 7 D o c 0 3 0 4 5 6 D o c 0 6 2 2 9 8 R l a 0 1 0 0 0 5 R l a 1 0 0 0 1 8 R l a 1 0 0 0 1 0 R l a 1 5 0 0 9 8 R l a 0 1 0 0 5 9 R l a 0 2 0 0 5 3 R l a 0 1 0 1 0 7 R l a 1 5 0 0 9 2 R l a 0 1 0 1 0 9 R l a 0 1 0 1 0 6 R l a 0 5 0 2 7 2 R l a 0 1 0 1 4 5 R l a 0 6 0 0 2 4 R l a 0 1 0 0 7 2 R l a 0 2 0 2 5 8 R l a 0 1 0 1 4 4 R l a 0 6 0 0 8 8 R l a 0 2 0 0 6 0 R l a 0 6 0 5 9 6 D o c 1 4 0 1 2 4 D o c 1 8 0 2 6 8 0 2 4 6 Stage I Stage II Stage III Stage IV A Weak Moderate Strong Negative SCC of Max. Sinus Stage III. T3N0M0 SCC of Tongue root Stage II. T2N0M0 ACC of Parotid Stage II. T2N0M0 Isotype Control Anti IL - 38 (Immunome Clone) Weak Moderate Strong Head & Neck Lung, Squamous Esophagus Cervix Skin Lung, Adeno 23% 53% 41% 48% 25% 14% 30% 9% Bladder Prostate log2TPM log2TPM 1. Source: Tempus Real - World Data 2. Cancer Genome Atlas (TCGA) data from Firehouse Legacy dataset 3. Immunome Internal Data IL - 38 Expression Confirmed in Multiple Tumors of High Unmet Medical Need 1 |
| IL - 38 Overexpression Inhibits Infiltration of T cells into Tumors In Vivo High IL - 38 Expression is Associated with Reduced Immune Cell Infiltration* → IL - 38 high tumor samples correlate with reduced infiltration of multiple immune subsets, especially in lung, head & neck, and gastroesophageal cancers IL - 38 Expression is Associated with Reduced Immune Cell Infiltration 21 Copyright © 2023 Immunome, Inc. All rights reserved. *Immunome analysis of the Cancer Genome Atlas (TCGA) data from Firehouse Legacy dataset Similar findings were also confirmed in real - world data (Tempus) - 0 .. 6 - 0 .. 4 - 0 .. 2 0 .. 0 0 .. 2 0 .. 4 0 .. 6 SK C M C ESC LUAD ESC A L U SC H N SC T Cells - 0 .. 3 - 0 .. 2 - 0 .. 1 0 .. 0 0 .. 1 0 .. 2 0 .. 3 SK C M C ESC LUAD ESC A L U SC H N SC B Cells - 0 .. 6 - 0 .. 4 - 0 .. 2 0 .. 0 0 .. 2 0 .. 4 0 .. 6 SK C M C ESC LUAD ESC A L U SC H N SC Macrophages - 0 .. 5 0 - 0 .. 2 5 0 .. 0 0 0 .. 2 5 0 .. 5 0 SK C M C ESC LUAD ESC A L U SC H N SC Monocytes - 0 .. 2 - 0 .. 1 0 .. 0 0 .. 1 0 .. 2 SK C M C ESC LUAD ESC A L U SC H N SC NK Cells SK C M C ESC LUAD ESC A L U SC H N SC Key D e c r e a s e d i n I L - 3 8 H i g h T u m o r s I n c r e a s e d i n I L - 3 8 H i g h T u m o r s ImSig Score Dif ference (IL-38 High minus IL-38 low) Kinoshita et al, Cancer Immunol. Immunother ..(2021) 70:123 1200 1000 800 600 400 200 CD3 (/mm 2 ) LLC - vector LLC – IL38 800 700 600 500 400 300 200 100 0 CD8 (/mm 2 ) LLC - vector LLC – IL38 |
| IMM - ONC - 01 Anti IL - 38 Antibody Blocking IL - 38 Leads to Tumor Control in Two Different Tumor Models 1 22 Copyright © 2023 Immunome, Inc. All rights reserved. Demonstration of Anti - Tumor Activity (B16.F10 Model) Induction of Anti - Tumor Memory (EMT6 Model) → Immunologically cold tumor model → IMM - ONC - 01 significantly inhibits B16.F10 tumor growth in vivo at 10 and 50 mg/kg doses → ~40% response rate upon treatment with IMM - ONC - 01 → Animals with complete cures resistant to tumor re - challenge – Strongly suggests immunological memory – Consistent with indirect effect on T cells 0 1 0 2 0 3 0 4 0 0 5 0 1 0 0 D a y % S u r v i v a l I M M - O N C - 0 1 V e h i c l e c o n t r o l 5 1 0 1 5 2 0 2 5 0 2 5 0 5 0 0 7 5 0 1 0 0 0 D a y T u m o r V o l u m e M e a n ± S E M ( m m 3 ) V e h i c l e c o n t r o l I M M - O N C - 0 1 1. AACR - NCI - EORTC Molecular Targets & Cancer Therapeutics Meeting, October 2021 ( https://doi.org/10.1158/1535 - 7163.TARG - 21 - LBA022 ) Isotype IMM - ONC - 01 50 10 50 mg/Kg Q3D * p < 0.05 |
| → In vitro and in vivo preclinical research confirms antitumor activity of IMM - ONC - 01 in solid tumors as a monotherapy → Gene expression profiling of patient tumors suggest normal IL - 38 biology is co - opted by tumors of squamous origin to suppress immune infiltration → IMM - ONC - 01 exhibits favorable pharmacokinetic profile → IMM - ONC - 01 is well tolerated in GLP toxicology studies → Potential indications include squamous cell carcinomas, such as head & neck, gastroesophageal and lung IND Submission Anticipated in Mid - 2023 23 IMM - ONC - 01 Program Summary Copyright © 2023 Immunome, Inc. All rights reserved. Takeda et al. PLoS One (2017) |
| 24 Financial Overview and Intellectual Property Snapshot Copyright © 2023 Immunome, Inc. All rights reserved. → Cash at least through 3Q 2024 → Eligible for additional platform access and option payments during the research term in the AbbVie Collaboration → Platform enables flexible business model – partnerships and proprietary programs Active ongoing research will generate additional IP, including trade secrets and patent applications around platform and pipeline Antibodies for lead oncology programs and uses thereof covered by international patent applications; projected expirations in 2039 and beyond Platform technology and discovery engine protected through base patents and know - how exclusively - licensed by Immunome and further patents and trade secrets owned by Immunome |
| Immunome “At a Glance” Disruptive Platform Leveraging Human Immune Response 25 Copyright © 2023 Immunome, Inc. All rights reserved. Discovery Of Novel Antibody - Target Pairs → Enabled by patient memory B cell interrogation → Widely applicable across therapeutic areas → Platform uniquely suited to rapidly identify novel Antibody - Drug Conjugate (ADC) targets Capital - Efficient Business Strategy → Strong cash position; runway through at least 3Q 2024 → Value creation through partnerships and proprietary programs Validating Collaborations → AbbVie collaboration $30M upfront and up to ~$2.8B in total → $17.6M funding from U.S. DoD JPEO - CBRND in collaboration with DHA Lead program, Anti IL - 38 Antibody IND Submission Mid - 2023 → IL - 38: A novel context dependent immune modulator in multiple solid tumors with poor prognosis → Potential indications: squamous carcinomas of head & neck, gastroesophageal and lung Deep Research Pipeline → Antibody targeting EPN1: Ectopically expressed, may allow for tumor specific targeting → Multiple additional novel targets enabling next - generation modalities (ADCs, T cell engagers) |
| Matthew Robinson, PhD Chief Technology Officer Antibody Structure Function Expert formerly at Fox Chase Cancer Center 26 Experienced Management Team Purnanand Sarma , PhD President & CEO Corleen Roche Chief Financial Officer Dennis Giesing , PhD Chief Development Officer Former CEO of Taris Biomedical Sold to Johnson & Johnson in 2019 Former US CFO, Biogen Former CFO, Global Vaccines, Wyeth/Pfizer Former CSO at Taris Biomedical Led BARDA funded pandemic flu program at MediVector Sandra Stoneman, Esq. Chief Legal Officer Former Partner at Duane Morris Life Sciences practice group leader Copyright © 2023 Immunome, Inc. All rights reserved. Mike Morin, PhD Chief Scientist Oversaw cancer, immunology and anti - bacterial drug discovery at Pfizer |
| 27 Board of Directors Copyright © 2023 Immunome, Inc. All rights reserved. Michael Rapp Chairman of the Board John LaMattina , PhD Franklyn G. Prendergast, MD Michael Lefenfeld Philip Wagenheim Managing Member, Broadband Capital Investments, LLC Formerly President, Pfizer Global Research & Development President and CEO, Hexion, Inc. Former President and CEO, Cyanco Co - founder of SiGNa Chemistry Managing Partner, Broadband Capital Partners, LLC Purnanand Sarma , PhD President & CEO, Immunome Former CEO of Taris Biomedical Sold to Johnson & Johnson in 2019 Former charter Director of the Mayo Center for Individualized Medicine Former member of the Mayo Board of Governors Former member of the Mayo Foundation’s Board of Trustees Former Director of the Mayo Clinic Comprehensive Cancer Center Former non - executive member of the Board of Directors, Eli Lilly Richard Baron Former VP and CFO, Zynerba Pharmaceuticals, Inc. Former SVP and CFO, Globus Medical Former CFO, various biotech, managed care and generics companies |
