<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001470263</cik>
        <entityName>Romark Laboratories, L.C.</entityName>
        <issuerAddress>
            <street1>3000 BAYPORT DRIVE</street1>
            <street2>SUITE 200</street2>
            <city>TAMPA</city>
            <stateOrCountry>FL</stateOrCountry>
            <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
            <zipCode>33607</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>813-282-8544</issuerPhoneNumber>
        <jurisdictionOfInc>FLORIDA</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Limited Liability Company</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jean</firstName>
                <middleName>Francois</middleName>
                <lastName>Rossignol</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 Bayport Drive</street1>
                <street2>Suite 200</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33607</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Marc</firstName>
                <middleName>S.</middleName>
                <lastName>Ayers</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 Bayport Drive</street1>
                <street2>Suite 200</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33607</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Celine</firstName>
                <lastName>Rossignol</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 Bayport Drive</street1>
                <street2>Suite 200</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33607</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Brian</firstName>
                <lastName>Schnieders</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 Bayport Drive</street1>
                <street2>Suite 200</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33607</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Emmet</firstName>
                <middleName>B.</middleName>
                <lastName>Keefe</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 Bayport Drive</street1>
                <street2>Suite 200</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33607</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeff</firstName>
                <lastName>Crowther</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 Bayport Drive</street1>
                <street2>Suite 200</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33607</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>W.</firstName>
                <middleName>Seymour</middleName>
                <lastName>Holt</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 Bayport Drive</street1>
                <street2>Suite 200</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33607</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>W.</firstName>
                <middleName>Andrew</middleName>
                <lastName>Krusen, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 Bayport Drive</street1>
                <street2>Suite 200</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33607</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0000897069-10-000068</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-08-26</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>100000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>DeWaay Financial Network, LLC</recipientName>
                <recipientCRDNumber>30767</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>13001 University Avenue</street1>
                    <city>Clive</city>
                    <stateOrCountry>IA</stateOrCountry>
                    <stateOrCountryDescription>IOWA</stateOrCountryDescription>
                    <zipCode>50325</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>SC</state>
                    <description>SOUTH CAROLINA</description>
                    <state>VA</state>
                    <description>VIRGINIA</description>
                    <state>LA</state>
                    <description>LOUISIANA</description>
                    <state>GA</state>
                    <description>GEORGIA</description>
                    <state>DC</state>
                    <description>DISTRICT OF COLUMBIA</description>
                    <state>OH</state>
                    <description>OHIO</description>
                    <state>MN</state>
                    <description>MINNESOTA</description>
                    <state>KY</state>
                    <description>KENTUCKY</description>
                    <state>WA</state>
                    <description>WASHINGTON</description>
                    <state>IL</state>
                    <description>ILLINOIS</description>
                    <state>OR</state>
                    <description>OREGON</description>
                    <state>NM</state>
                    <description>NEW MEXICO</description>
                    <state>MA</state>
                    <description>MASSACHUSETTS</description>
                    <state>MS</state>
                    <description>MISSISSIPPI</description>
                    <state>DE</state>
                    <description>DELAWARE</description>
                    <state>WV</state>
                    <description>WEST VIRGINIA</description>
                    <state>HI</state>
                    <description>HAWAII</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>KS</state>
                    <description>KANSAS</description>
                    <state>SD</state>
                    <description>SOUTH DAKOTA</description>
                    <state>AK</state>
                    <description>ALASKA</description>
                    <state>TN</state>
                    <description>TENNESSEE</description>
                    <state>ID</state>
                    <description>IDAHO</description>
                    <state>RI</state>
                    <description>RHODE ISLAND</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>NC</state>
                    <description>NORTH CAROLINA</description>
                    <state>NH</state>
                    <description>NEW HAMPSHIRE</description>
                    <state>MT</state>
                    <description>MONTANA</description>
                    <state>WI</state>
                    <description>WISCONSIN</description>
                    <state>CO</state>
                    <description>COLORADO</description>
                    <state>OK</state>
                    <description>OKLAHOMA</description>
                    <state>NE</state>
                    <description>NEBRASKA</description>
                    <state>NV</state>
                    <description>NEVADA</description>
                    <state>MI</state>
                    <description>MICHIGAN</description>
                    <state>MD</state>
                    <description>MARYLAND</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>VT</state>
                    <description>VERMONT</description>
                    <state>AZ</state>
                    <description>ARIZONA</description>
                    <state>IN</state>
                    <description>INDIANA</description>
                    <state>AL</state>
                    <description>ALABAMA</description>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>UT</state>
                    <description>UTAH</description>
                    <state>WY</state>
                    <description>WYOMING</description>
                    <state>ND</state>
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                    <state>PA</state>
                    <description>PENNSYLVANIA</description>
                    <state>AR</state>
                    <description>ARKANSAS</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
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                    <description>NEW JERSEY</description>
                    <state>ME</state>
                    <description>MAINE</description>
                    <state>IA</state>
                    <description>IOWA</description>
                    <state>MO</state>
                    <description>MISSOURI</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>EDI Financial, Inc.</recipientName>
                <recipientCRDNumber>15699</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>12221 Merit Drive</street1>
                    <street2>Suite 1020</street2>
                    <city>Dallas</city>
                    <stateOrCountry>TX</stateOrCountry>
                    <stateOrCountryDescription>TEXAS</stateOrCountryDescription>
                    <zipCode>75251-2207</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>SC</state>
                    <description>SOUTH CAROLINA</description>
                    <state>VA</state>
                    <description>VIRGINIA</description>
                    <state>NC</state>
                    <description>NORTH CAROLINA</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>LA</state>
                    <description>LOUISIANA</description>
                    <state>GA</state>
                    <description>GEORGIA</description>
                    <state>MT</state>
                    <description>MONTANA</description>
                    <state>CO</state>
                    <description>COLORADO</description>
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                    <description>OHIO</description>
                    <state>OK</state>
                    <description>OKLAHOMA</description>
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                    <description>MINNESOTA</description>
                    <state>NV</state>
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                    <state>MD</state>
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                    <state>TX</state>
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                    <state>MO</state>
                    <description>MISSOURI</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>GunnAllen Financial, Inc.</recipientName>
                <recipientCRDNumber>17609</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>5002 West Waters Avenue</street1>
                    <city>Tampa</city>
                    <stateOrCountry>FL</stateOrCountry>
                    <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                    <zipCode>33634</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>International Assets Advisors, LLC</recipientName>
                <recipientCRDNumber>10645</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>300 South Orange Avenue</street1>
                    <street2>Suite 1100</street2>
                    <city>Orlando</city>
                    <stateOrCountry>FL</stateOrCountry>
                    <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                    <zipCode>32801</zipCode>
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                <statesOfSolicitationList>
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                    <description>SOUTH CAROLINA</description>
                    <state>VA</state>
                    <description>VIRGINIA</description>
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                    <description>LOUISIANA</description>
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                    <description>GEORGIA</description>
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                    <description>DISTRICT OF COLUMBIA</description>
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                    <description>MINNESOTA</description>
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                    <description>WASHINGTON</description>
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                    <state>WV</state>
                    <description>WEST VIRGINIA</description>
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                    <state>SD</state>
                    <description>SOUTH DAKOTA</description>
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                    <state>RI</state>
                    <description>RHODE ISLAND</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>NC</state>
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                    <description>NEW HAMPSHIRE</description>
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                    <description>NEVADA</description>
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                    <state>MD</state>
                    <description>MARYLAND</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>VT</state>
                    <description>VERMONT</description>
                    <state>AZ</state>
                    <description>ARIZONA</description>
                    <state>IN</state>
                    <description>INDIANA</description>
                    <state>AL</state>
                    <description>ALABAMA</description>
                    <state>CA</state>
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                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>35000000</totalOfferingAmount>
            <totalAmountSold>23111817</totalAmountSold>
            <totalRemaining>11888183</totalRemaining>
            <clarificationOfResponse>Of the $20 million Total Offering Amount for the first offering, $14,777,619 was sold. A second offering that is integrated with the first was conducted with an offering amount of $15,000,000, $8,334,198 of which was sold.  This offering is completed.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>155</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>2386182</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>10% of gross proceeds raised in the Offering plus $75,000, plus a warrant to purchase an amount of Issuer's Units equal to 15% of the number of Class C Units issued in the Offering</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Romark Laboratories, L.C.</issuerName>
                <signatureName>Brian Schnieders</signatureName>
                <nameOfSigner>Brian Schnieders</nameOfSigner>
                <signatureTitle>CFO</signatureTitle>
                <signatureDate>2011-01-04</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
