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Stock-Based Compensation and Warrants - Summary of Activity Under Stock Incentive Plans (Detail)
$ / shares in Units, $ in Thousands
6 Months Ended
Jun. 30, 2018
USD ($)
$ / shares
shares
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]  
Shares Subject to Outstanding, Beginning Balance | shares 288,129
Shares Subject to Outstanding, Options granted | shares 44,910
Shares Subject to Outstanding, Options exercised | shares (44,354)
Shares Subject to Outstanding, Options cancelled and forfeited | shares (5,426)
Shares Subject to Outstanding, Ending Balance | shares 283,259
Shares Subject to Outstanding, Vested and expected to vest | shares 277,258
Shares Subject to Outstanding, Exercisable | shares 132,977
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance | $ / shares $ 63.62
Weighted-Average Exercise Price Per Share, Options granted | $ / shares 18.27
Weighted-Average Exercise Price Per Share, Options exercised | $ / shares 21.73
Weighted-Average Exercise Price Per Share, Options cancelled and forfeited | $ / shares 32.21
Weighted Average Exercise Price Per Share, Outstanding Ending Balance | $ / shares 63.69
Weighted Average Exercise Price Per Share, Vested and expected to vest | $ / shares 64.20
Weighted Average Exercise Price Per Share, Exercisable | $ / shares $ 89.94
Aggregate Intrinsic Value, Outstanding Balance | $ $ 6
Aggregate Intrinsic Value, Vested and expected to vest | $ $ 5