Stock-Based Compensation and Employee Stock Purchase Program - Summary of Activity Under Stock Incentive Plans (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Share-Based Payment Arrangement [Abstract]
Shares Subject to Outstanding, Beginning Balance	35,554	22,243
Shares Subject to Outstanding, Options granted	33,408	30,676
Shares Subject to Outstanding, Options exercised	0	0
Shares Subject to Outstanding, Options Forfeited	(6,658)	(11,004)
Shares Subject to Outstanding, Options Expired	(2,302)	(6,361)
Shares Subject to Outstanding, Ending Balance	60,002	35,554
Shares Subject to Outstanding, Vested and expected to vest	54,018
Shares Subject to Outstanding, Exercisable	22,456
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance	$ 211.20	$ 578.40
Weighted-Average Exercise Price Per Share, Options granted	44.00	110.40
Weighted-Average Exercise Price Per Share, Options exercised	0	0
Weighted-Average Exercise Price Per Share, Options forfeited	91.60	123.60
Weighted-Average Exercise Price Per Share, Options expired	644.80	1,160.80
Weighted Average Exercise Price Per Share, Outstanding Ending Balance	114.80	$ 211.20
Weighted Average Exercise Price Per Share, Vested and expected to vest	121.60
Weighted Average Exercise Price Per Share, Exercisable	$ 215.20
Aggregate Intrinsic Value, Beginning Balance	$ 0	$ 9,600,000
Aggregate Intrinsic Value, Options Granted	11,880,000	0
Aggregate Intrinsic Value, Options Exercised	0	0
Aggregate Intrinsic Value, Options Forfeited	0	43,440,000
Aggregate Intrinsic Value, Options Expired	0	0
Aggregate Intrinsic Value, Ending Balance	0	$ 0
Aggregate Intrinsic Value, Vested and expected to vest	0
Aggregate Intrinsic Value, Exercisable	$ 0