Stock-Based Compensation and Employee Stock Purchase Program (Tables)

12 Months Ended

Dec. 31, 2022

Share-Based Payment Arrangement [Abstract]

Summary of Activity Under Stock Incentive Plans

The following is a summary of stock option information and weighted average exercise prices under the Company’s stock incentive plans (in thousands, except share data and price per share):

	Shares Subject to Outstanding Options			Weighted- Average Exercise Price Per Share		Aggregate Intrinsic Value
Outstanding — Balance at December 31, 2020		22,243		$	578.40	$	9,600
Options granted		30,676			110.40		—
Options exercised		—			—		—
Options forfeited		(11,004	)		123.60		43,440
Options expired		(6,361	)		1,160.80		—
Outstanding — Balance at December 31, 2021		35,554			211.20		—
Options granted		33,408			44.00		11,880
Options exercised		—			—		—
Options forfeited		(6,658	)		91.60		—
Options expired		(2,302	)		644.80		—
Outstanding — Balance at December 31, 2022		60,002			114.80		—
Vested and expected to vest — December 31, 2022		54,018			121.60		—
Exercisable —December 31, 2022		22,456		$	215.20	$	—

Weighted-Average Fair Value Assumption of Stock Option Awards

The fair value of stock option awards was estimated at the date of grant using the Black-Scholes option-pricing model with the following weighted-average assumption:

	Year Ended December 31,
Assumptions	2022			2021
Expected term (years)		6.40			6.31
Expected volatility		122	%		121	%
Risk-free interest rate		2.61	%		0.86	%
Expected dividend yield		—			—