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Stock-Based Compensation and Employee Stock Purchase Program - Summary of Activity Under Stock Incentive Plans (Detail)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2022
USD ($)
$ / shares
shares
Share-based Payment Arrangement [Abstract]  
Shares Subject to Outstanding, Beginning Balance | shares 1,422,195
Shares Subject to Outstanding, Options granted | shares 326,108
Shares Subject to Outstanding, Options Forfeited | shares (31,366)
Shares Subject to Outstanding, Options Expired | shares (7,385)
Shares Subject to Outstanding, Ending Balance | shares 1,709,552
Shares Subject to Outstanding, Vested and expected to vest | shares 1,518,077
Shares Subject to Outstanding, Exercisable | shares 777,274
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance | $ / shares $ 5.28
Weighted-Average Exercise Price Per Share, Options granted | $ / shares 0.91
Weighted-Average Exercise Price Per Share, Options forfeited | $ / shares 3.13
Weighted-Average Exercise Price Per Share, Options expired | $ / shares 15.07
Weighted Average Exercise Price Per Share, Outstanding Ending Balance | $ / shares 4.44
Weighted Average Exercise Price Per Share, Vested and expected to vest | $ / shares 4.77
Weighted Average Exercise Price Per Share, Exercisable | $ / shares $ 7.24
Aggregate Intrinsic Value, Outstanding Balance | $ $ 161,253
Aggregate Intrinsic Value, Vested and expected to vest | $ $ 118,914