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Stock-Based Compensation and Employee Stock Purchase Program - Summary of Activity Under Stock Incentive Plans (Detail) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]      
Shares Subject to Outstanding, Beginning Balance 889,759 661,701  
Shares Subject to Outstanding, Options granted 1,227,042 502,494  
Shares Subject to Outstanding, Options Forfeited (440,166) (174,508)  
Shares Subject to Outstanding, Options Expired (254,440) (99,928)  
Shares Subject to Outstanding, Ending Balance 1,422,195 889,759  
Shares Subject to Outstanding, Vested and expected to vest 1,322,111    
Shares Subject to Outstanding, Exercisable 743,109    
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance $ 14.46 $ 21.60  
Weighted-Average Exercise Price Per Share, Options granted 2.76 4.28  
Weighted-Average Exercise Price Per Share, Options forfeited 3.09 5.91  
Weighted-Average Exercise Price Per Share, Options expired 29.02 25.56  
Weighted Average Exercise Price Per Share, Outstanding Ending Balance 5.28 $ 14.46  
Weighted Average Exercise Price Per Share, Vested and expected to vest 5.47    
Weighted Average Exercise Price Per Share, Exercisable $ 7.54    
Aggregate Intrinsic Value, Outstanding Balance   $ 240 $ 305
Aggregate Intrinsic Value, Options Forfeited $ 1,086