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Stock-Based Compensation - Summary of Stock Option Activity (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2017
Dec. 31, 2016
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]    
Number of stock options, Outstanding, balance 12,897,000  
Number of stock options, Granted 4,269,000  
Number stock options, Exercised (41,000)  
Number of stock options, Cancelled/Forfeited (118,000)  
Number of stock options, Outstanding, Balance 17,007,000 12,897,000
Number of stock options, Options vested and exercisable 7,581,000  
Weighted-average exercise price, Outstanding, Balance $ 5.94  
Weighted-average exercise price, Granted 5.00  
Weighted-average exercise price, Exercised 1.96  
Weighted-average exercise price, Cancelled/Forfeited 8.87  
Weighted-average exercise price, Outstanding, Balance 5.70 $ 5.94
Weighted-average exercise price, Options vested and exercisable $ 5.24  
Weighted-average remaining contractual life, Options outstanding 7 years 11 months 9 days 7 years 5 months 27 days
Weighted-average remaining contractual life, Options vested and exercisable 6 years 5 months 1 day  
Aggregate intrinsic value, Options outstanding $ 11,677  
Aggregate intrinsic value, Options vested and exercisable $ 9,392