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                <is40Act>false</is40Act>
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        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C</item>
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        <typeOfFiling>
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                <previousAccessionNumber>0001469273-10-000002</previousAccessionNumber>
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            <dateOfFirstSale>
                <value>2009-12-01</value>
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        <durationOfOffering>
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        <typesOfSecuritiesOffered>
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        <businessCombinationTransaction>
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        <minimumInvestmentAccepted>100000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Morgan Stanley Smith Barney LLC</recipientName>
                <recipientCRDNumber>149777</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>2000 Westchester Avenue</street1>
                    <city>Purchase</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10577-2530</zipCode>
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                <statesOfSolicitationList>
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                <foreignSolicitation>false</foreignSolicitation>
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        <offeringSalesAmounts>
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        <investors>
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            <findersFees>
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            <clarificationOfResponse>Each investor pays up to 2% of its aggregate investment to agent upfront, in addition to any amounts invested in the Fund.  General Partner pays agent a portion of the fees paid to it by the Fund on an ongoing basis.</clarificationOfResponse>
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                <issuerName>Morgan Stanley HedgePremier/FrontPoint Healthcare Enhanced Offshore Fund L.P.</issuerName>
                <signatureName>Patrick Reid</signatureName>
                <nameOfSigner>Patrick Reid</nameOfSigner>
                <signatureTitle>Director of the General Partner</signatureTitle>
                <signatureDate>2010-12-17</signatureDate>
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