<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001794090</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001468929</issuerCik>
      <issuerName>NEXGEL, INC.</issuerName>
      <secFileNumber>001-41173</secFileNumber>
      <issuerAddress>
        <com:street1>2150 CABOT BLVD WEST,</com:street1>
        <com:street2>SUITE B</com:street2>
        <com:city>LANGHORNE</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>19047</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>215 702-8550</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Levy Adam R.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab Corp.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>10000</noOfUnitsSold>
      <aggregateMarketValue>16400.00</aggregateMarketValue>
      <noOfUnitsOutstanding>8143133</noOfUnitsOutstanding>
      <approxSaleDate>12/22/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>10000</securitiesClassTitle>
      <acquiredDate>10/15/2019</acquiredDate>
      <natureOfAcquisitionTransaction>Equity Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
      <paymentDate>10/15/2019</paymentDate>
      <natureOfPayment>Equity Copensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Adam Levy</name>
        <address>
          <com:street1>2150 Cabot Blvd West, Suite B</com:street1>
          <com:city>Langhorne</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19047</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/02/2025</saleDate>
      <amountOfSecuritiesSold>1600</amountOfSecuritiesSold>
      <grossProceeds>4000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Adam Levy</name>
        <address>
          <com:street1>2150 Cabot Blvd West, Suite B</com:street1>
          <com:city>Langhorne</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19047</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/03/2025</saleDate>
      <amountOfSecuritiesSold>2400</amountOfSecuritiesSold>
      <grossProceeds>6119.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Adam Levy</name>
        <address>
          <com:street1>2150 Cabot Blvd West, Suite B</com:street1>
          <com:city>Lanhorne</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19047</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>11/06/2025</saleDate>
      <amountOfSecuritiesSold>4000</amountOfSecuritiesSold>
      <grossProceeds>10084.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Client / shareholder did not pay for the shares. They were acquired as part of his equity compensation</remarks>
    <noticeSignature>
      <noticeDate>12/22/2025</noticeDate>
      <signature>Adam R Levy</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
