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Commitments and Contingencies - Additional Information (Details)
$ in Thousands, SFr in Millions
1 Months Ended 6 Months Ended
Aug. 31, 2020
Jun. 30, 2022
USD ($)
Jun. 30, 2022
CHF (SFr)
Dec. 31, 2021
USD ($)
Apr. 30, 2021
CHF (SFr)
Commitments And Contingencies Disclosure [Line Items]          
Operating lease right-of-use asset   $ 63,076   $ 66,744  
Lease Agreement          
Commitments And Contingencies Disclosure [Line Items]          
Operating lease right-of-use asset   0      
Lease liabilities   0      
Clinical and Commercial Supply of Drug Substance | Manufacturing Agreement | Lonza          
Commitments And Contingencies Disclosure [Line Items]          
Annual suite fees payment | SFr         SFr 150.0
Revised estimated capital contribution | SFr         SFr 75.0
Manufacturing agreement initial term 8 years        
Clinical and Commercial Supply of Drug Substance | Maximum | Manufacturing Agreement | Lonza          
Commitments And Contingencies Disclosure [Line Items]          
Manufacturing agreement term that can be extended 16 years        
Other Assets [Member] | Manufacturing Agreement          
Commitments And Contingencies Disclosure [Line Items]          
Manufacturing Agreement Expense   $ 44,100 SFr 40.0