144 0001468308 XXXXXXXX LIVE 0001211583 FENNEC PHARMACEUTICALS INC. 001-32295 PO BOX 13628, 68 TW ALEXANDER DRIVE Research Triangle Park NC 27709 (919) 636-4530 ROBERT ANDRADE Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

75000 883897.50 35067159 08/27/2026 NASDAQ Common 08/13/2020 Exercised Shares ISSUER N 75000 08/13/2020 Cash Y The securities to be sold were acquired upon the exercise of Stock Options during the period of 08/13/2020 through 03/26/2026. 08/27/2026 05/22/2026 /s/ Robert Andrade