<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0706</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001468270</cik>
        <entityName>UpStart Life Sciences Capital, L.P.</entityName>
        <issuerAddress>
            <street1>417 WAKARA WAY</street1>
            <street2>SUITE 3510</street2>
            <city>SALT LAKE CITY</city>
            <stateOrCountry>UT</stateOrCountry>
            <stateOrCountryDescription>UTAH</stateOrCountryDescription>
            <zipCode>84108</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>801-585-6330</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Limited Partnership</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2009</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Steven</firstName>
                <middleName>J.</middleName>
                <lastName>Borst</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>417 Wakara Way</street1>
                <street2>Suite 3510</street2>
                <city>Salt Lake City</city>
                <stateOrCountry>UT</stateOrCountry>
                <stateOrCountryDescription>UTAH</stateOrCountryDescription>
                <zipCode>84108</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Manager of General Partner</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dennis</firstName>
                <middleName>B.</middleName>
                <lastName>Farrar</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>417 Wakara Way</street1>
                <street2>Suite 3510</street2>
                <city>Salt Lake City</city>
                <stateOrCountry>UT</stateOrCountry>
                <stateOrCountryDescription>UTAH</stateOrCountryDescription>
                <zipCode>84108</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Manager of General Partner</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Theodore</firstName>
                <middleName>H.</middleName>
                <lastName>Stanley</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>417 Wakara Way</street1>
                <street2>Suite 3510</street2>
                <city>Salt Lake City</city>
                <stateOrCountry>UT</stateOrCountry>
                <stateOrCountryDescription>UTAH</stateOrCountryDescription>
                <zipCode>84108</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Manager of General Partner</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Venture Capital Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C</item>
            <item>3C.1</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001468270-11-000002</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-07-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>TriCor Financial LLC</recipientName>
                <recipientCRDNumber>142518</recipientCRDNumber>
                <associatedBDName>TriCor Financial LLC</associatedBDName>
                <associatedBDCRDNumber>142518</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>7201 W. Lake Mead</street1>
                    <street2>Suite 114</street2>
                    <city>Las Vegas</city>
                    <stateOrCountry>NV</stateOrCountry>
                    <stateOrCountryDescription>NEVADA</stateOrCountryDescription>
                    <zipCode>89128</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>AZ</state>
                    <description>ARIZONA</description>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>CO</state>
                    <description>COLORADO</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>NV</state>
                    <description>NEVADA</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>OK</state>
                    <description>OKLAHOMA</description>
                    <state>OR</state>
                    <description>OREGON</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>UT</state>
                    <description>UTAH</description>
                    <state>VA</state>
                    <description>VIRGINIA</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>28500000</totalOfferingAmount>
            <totalAmountSold>9880000</totalAmountSold>
            <totalRemaining>18620000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>67</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>6000</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse>The General Partner of the Issuer is entitled to a management fee.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>UpStart Life Sciences Capital, L.P.</issuerName>
                <signatureName>/s/ Steven J. Borst</signatureName>
                <nameOfSigner>Steven J. Borst</nameOfSigner>
                <signatureTitle>Manager of UpStart Ventures Management, LLC, General Partner</signatureTitle>
                <signatureDate>2012-07-13</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
