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Related party transactions (Details)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended
Nov. 08, 2018
USD ($)
$ / shares
shares
Nov. 05, 2018
USD ($)
EquityInstruments
$ / shares
Oct. 26, 2017
USD ($)
$ / shares
shares
Jul. 26, 2017
USD ($)
Jun. 30, 2017
USD ($)
$ / shares
shares
May 31, 2019
USD ($)
Feb. 28, 2017
USD ($)
$ / shares
shares
Mar. 31, 2019
USD ($)
Stock transaction disclosures                
Net proceeds from issuance of stock               $ 11
Common Stock | Minimum                
Stock transaction disclosures                
Proceeds from issuance of common stock   $ 4,500            
Underwritten Public Offering | Common Stock                
Stock transaction disclosures                
Issuance of common stock, net of issuance costs (in shares) | shares 19,999,999       4,800,000   5,750,000  
Public offering price (in dollars per share) | $ / shares $ 2.30       $ 6.25   $ 5.00  
Proceeds from issuance of common stock         $ 30,000      
Payments of stock issuance costs         $ 200      
Term of option to purchase share         30 days      
Shares offered to underwriters under option granted (in shares) | shares         720,000      
Net proceeds from issuance of stock $ 43,400     $ 34,300     $ 26,700  
Underwritten Public Offering | Common Stock | Minimum                
Stock transaction disclosures                
Proceeds from issuance of common stock   30,000            
Over-allotment option | Common Stock                
Stock transaction disclosures                
Issuance of common stock, net of issuance costs (in shares) | shares 2,608,695           750,000  
Senior Secured Credit Facility | Conversion Of Convertible Notes                
Stock transaction disclosures                
Number of shares issued upon conversion of debt | shares     929,967          
Amount of debt converted into stock     $ 6,600          
Conversion price | $ / shares     $ 7.08          
Conversion price, expressed as a percentage of stock price     95.00%          
Number of trading days used to determine conversion stock price     3 days          
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2019                
Stock transaction disclosures                
Payment of facility   $ 7,500       $ 7,500    
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2019 | Common Stock                
Stock transaction disclosures                
Number of trading days used to determine conversion stock price   10 days            
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2019 | Common Stock | Maximum                
Stock transaction disclosures                
Number of shares which may be issued for conversion of convertible notes | EquityInstruments   2,135,625            
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2020                
Stock transaction disclosures                
Principal repayment to be paid   $ 15,000            
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2020 | Common Stock                
Stock transaction disclosures                
Conversion price | $ / shares   $ 10.00            
Conversion price, expressed as a percentage of stock price   95.00%            
Number of trading days used to determine conversion stock price   3 days            
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2020 | Common Stock | Maximum                
Stock transaction disclosures                
Number of shares which may be issued for conversion of convertible notes | EquityInstruments   3,796,668            
Conversion price, expressed as a percentage of stock price   95.00%            
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2020 | Common Stock | Minimum                
Stock transaction disclosures                
Conversion price, expressed as a percentage of stock price   83.00%            
Investor | Debt issued to entities affiliated with Deerfield | Senior Secured Credit Facility                
Related party transactions                
Face amount of debt at time of related party stock purchase             $ 60,000