Debt - Senior Secured Credit facility (Details)									1 Months Ended		3 Months Ended
	May 11, 2020 USD ($)	May 06, 2020 USD ($) $ / shares	Nov. 08, 2018 $ / shares shares	Nov. 05, 2018 USD ($) EquityInstruments $ / shares	Oct. 26, 2017 USD ($) $ / shares shares	Jun. 30, 2017 USD ($) $ / shares shares	Jun. 01, 2017 USD ($) EquityInstruments $ / shares	May 11, 2016 USD ($) item installment	May 31, 2019 USD ($)	Feb. 28, 2017 $ / shares shares	Mar. 31, 2020 USD ($)	Mar. 31, 2019 USD ($)	Dec. 31, 2019 USD ($)
Long-term debt
Derivative liability											$ 1,231,000		$ 1,135,000
Unamortized discount on debt											1,635,000
Interest Expense											$ 2,037,000	$ 2,115,000
Debt issued to entities affiliated with Deerfield
Long-term debt
Debt instrument covenant compliance											As of March 31, 2020, the Company was in compliance with the covenants under the Facility.
Senior Secured Convertible Note
Long-term debt
Face amount of debt issued							$ 6,600,000
Interest rate (as a percent)							12.95%
Term of debt (in years)							1 year
Effective interest rate during debt term (as a percent)											25.35%
Time period before debt maturity when debt conversion option expires							5 days
Increase in prepayment fee (in basis points)							300
Conversion price, expressed as a percentage of stock price							95.00%
Number of trading days used to determine conversion stock price							3 days
Unamortized discount on debt							$ 600,000
Recognition of beneficial conversion feature on convertible notes							$ 600,000
Maximum percentage of stock for note holder							9.985%
Maximum percentage of stock for aggregate conversion							19.90%
Senior Secured Convertible Note | Registration Agreement
Long-term debt
Liability recorded for expected unmet agreement obligations				$ 0
Underwritten Public Offering | Common Stock
Long-term debt
Issuance of common stock, net of issuance costs (in shares) | shares			19,999,999			4,800,000				5,750,000
Public offering price (in dollars per share) | $ / shares			$ 2.30			$ 6.25				$ 5.00
Gross proceeds from issuance of stock						$ 30,000,000
Minimum | Senior Secured Convertible Note
Long-term debt
Prepayment fee of debt (in percentage)							2.00%
Conversion price | $ / shares							$ 7.00
Minimum | Common Stock
Long-term debt
Gross proceeds from issuance of stock				4,500,000
Minimum | Underwritten Public Offering | Common Stock
Long-term debt
Gross proceeds from issuance of stock				$ 30,000,000
Maximum | Senior Secured Convertible Note
Long-term debt
Prepayment fee of debt (in percentage)							12.75%
Senior Secured Credit Facility
Long-term debt
Interest Expense											$ 1,800,000	2,100,000
Senior Secured Credit Facility | Registration Agreement
Long-term debt
Maximum reimbursable legal fees							$ 25,000
Senior Secured Credit Facility | Debt issued to entities affiliated with Deerfield
Long-term debt
Face amount of debt issued								$ 60,000,000
Date of first installment of principal payment								May 01, 2019
Number of equal annual installments | installment								3
Interest rate (as a percent)								12.95%
Deferred interest payments							6,600,000
Number of first interest payments for which the reporting entity has the option to defer | item								4
Debt yield enhancement fee								$ 1,400,000
Term of debt (in years)								6 years
Minimum cash on deposit to maintain under debt arrangement								$ 5,000,000
Effective interest rate during debt term (as a percent)				16.69%							15.03%
Debt discount amortization											$ 300,000	$ 400,000
Unamortized discount on debt											1,635,000		$ 1,982,000
Senior Secured Credit Facility | Debt issued to entities affiliated with Deerfield | Company's Attorneys
Long-term debt
Debt legal costs								200,000
Senior Secured Credit Facility | Debt issued to entities affiliated with Deerfield | On Behalf Of Deerfield's Attorneys
Long-term debt
Debt legal costs								$ 100,000
Senior Secured Credit Facility | Deerfield Private Design Fund III, LP
Long-term debt
Debt borrowing structure (as a percent)								66.67%
Senior Secured Credit Facility | Deerfield Special Situations Fund, LP
Long-term debt
Debt borrowing structure (as a percent)								33.33%
Senior Secured Credit Facility | Senior Secured Convertible Note
Long-term debt
Derivative liability							$ 2,100,000				1,200,000
Minimum premiums as percent required to treat as derivative							10.00%
Payment of debt modification fee							$ 40,000
Maximum time period to register shares per agreement				30 days			30 days
Maximum time period for registration to become effective per agreement				75 days			75 days
Senior Secured Credit Facility | Minimum | Senior Secured Convertible Note
Long-term debt
Conversion price | $ / shares							$ 7.00
Senior Secured Credit Facility | Maximum | Senior Secured Convertible Note
Long-term debt
Number of shares which may be issued for conversion of convertible notes | EquityInstruments							940,924
Second Amendment Facility Due in May 2019 | Debt issued to entities affiliated with Deerfield
Long-term debt
Face amount of debt issued				$ 52,500,000
Prepayment of premium amount (as a percent)				6.25%
Non-refundable exit fee				$ 750,239
Payment of senior debt and fee				$ 7,500,000					$ 7,500,000
Principal outstanding											$ 45,000,000
Second Amendment Facility Due in May 2019 | Common Stock | Debt issued to entities affiliated with Deerfield
Long-term debt
Share price, percentage of Last Bid Price				93.00%
Principal payment (in dollars per shares) | $ / shares				$ 3.00
Ownership Cap percentage				4.985%
Number of trading days used to determine conversion stock price				10 days
Second Amendment Facility Due in May 2019 | 2019 | Debt issued to entities affiliated with Deerfield
Long-term debt
Face amount of debt issued				$ 7,500,000
Second Amendment Facility Due in May 2019 | 2020 | Debt issued to entities affiliated with Deerfield
Long-term debt
Face amount of debt issued				15,000,000
Second Amendment Facility Due in May 2019 | 2021 | Debt issued to entities affiliated with Deerfield
Long-term debt
Face amount of debt issued				15,000,000
Second Amendment Facility Due in May 2019 | 2022 | Debt issued to entities affiliated with Deerfield
Long-term debt
Face amount of debt issued				$ 15,000,000
Second Amendment Facility Due in May 2019 | Maximum | Common Stock | Debt issued to entities affiliated with Deerfield
Long-term debt
Number of shares which may be issued for conversion of convertible notes | EquityInstruments				2,135,625
Second Amendment Facility Due in May 2020 | Common Stock | Debt issued to entities affiliated with Deerfield
Long-term debt
Ownership Cap percentage				4.985%
Conversion price | $ / shares				$ 10.00
Conversion price, expressed as a percentage of stock price				95.00%
Number of trading days used to determine conversion stock price				3 days
Second Amendment Facility Due in May 2020 | Minimum | Common Stock | Debt issued to entities affiliated with Deerfield
Long-term debt
Conversion price, expressed as a percentage of stock price				83.00%
Second Amendment Facility Due in May 2020 | Maximum | Common Stock | Debt issued to entities affiliated with Deerfield
Long-term debt
Percentage of principal amount available for conversion				50.00%
Conversion price, expressed as a percentage of stock price				95.00%
Number of shares which may be issued for conversion of convertible notes | EquityInstruments				3,796,668
Conversion Of Convertible Notes | Senior Secured Credit Facility
Long-term debt
Amount of debt converted into stock					$ 6,600,000
Number of shares issued upon conversion of debt | shares					929,967
Conversion price | $ / shares					$ 7.08
Conversion price, expressed as a percentage of stock price					95.00%
Number of trading days used to determine conversion stock price					3 days
Subsequent event | Fifth Amendment To Credit Facility
Long-term debt
Repayments of debt	$ 10,000,000
Non-refundable exit fee		$ 250,000
Deferred Principal		$ 5,000,000
Conversion price | $ / shares		$ 1.50