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Related party transactions (Details)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Nov. 08, 2018
USD ($)
$ / shares
shares
Nov. 05, 2018
USD ($)
EquityInstruments
$ / shares
Oct. 26, 2017
USD ($)
$ / shares
shares
Jul. 26, 2017
USD ($)
Jun. 30, 2017
USD ($)
$ / shares
shares
Feb. 17, 2017
USD ($)
shares
May 31, 2019
USD ($)
Feb. 28, 2017
USD ($)
$ / shares
shares
Sep. 30, 2018
shares
Sep. 30, 2019
USD ($)
Sep. 30, 2018
USD ($)
shares
Stock transaction disclosures                      
Net proceeds from issuance of stock                   $ 11 $ 3,892
Common Stock                      
Stock transaction disclosures                      
Issuance of common stock, net of issuance costs (in shares) | shares                 651,525   651,525
Minimum | Common Stock                      
Stock transaction disclosures                      
Proceeds from issuance of common stock   $ 4,500                  
Underwritten Public Offering | Common Stock                      
Stock transaction disclosures                      
Issuance of common stock, net of issuance costs (in shares) | shares 19,999,999       4,800,000     5,750,000      
Public offering price (in dollars per share) | $ / shares $ 2.30       $ 6.25     $ 5.00      
Proceeds from issuance of common stock         $ 30,000            
Payments of stock issuance costs         $ 200            
Term of option to purchase share         30 days            
Shares offered to underwriters under option granted (in shares) | shares         720,000            
Net proceeds from issuance of stock $ 43,400     $ 34,300   $ 26,700          
Underwritten Public Offering | Minimum | Common Stock                      
Stock transaction disclosures                      
Proceeds from issuance of common stock   30,000                  
Over-allotment option | Common Stock                      
Stock transaction disclosures                      
Issuance of common stock, net of issuance costs (in shares) | shares 2,608,695         750,000          
Senior Secured Credit Facility | Conversion Of Convertible Notes                      
Stock transaction disclosures                      
Number of shares issued upon conversion of debt | shares     929,967                
Amount of debt converted into stock     $ 6,600                
Conversion price | $ / shares     $ 7.08                
Conversion price, expressed as a percentage of stock price     95.00%                
Number of trading days used to determine conversion stock price     3 days                
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2019                      
Stock transaction disclosures                      
Payment of facility   $ 7,500         $ 7,500        
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2019 | Common Stock                      
Stock transaction disclosures                      
Number of trading days used to determine conversion stock price   10 days                  
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2019 | Maximum | Common Stock                      
Stock transaction disclosures                      
Number of shares which may be issued for conversion of convertible notes | EquityInstruments   2,135,625                  
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2020                      
Stock transaction disclosures                      
Principal repayment to be paid   $ 15,000                  
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2020 | Common Stock                      
Stock transaction disclosures                      
Conversion price | $ / shares   $ 10.00                  
Conversion price, expressed as a percentage of stock price   95.00%                  
Number of trading days used to determine conversion stock price   3 days                  
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2020 | Maximum | Common Stock                      
Stock transaction disclosures                      
Number of shares which may be issued for conversion of convertible notes | EquityInstruments   3,796,668                  
Conversion price, expressed as a percentage of stock price   83.00%                  
Investor | Debt issued to entities affiliated with Deerfield | Senior Secured Credit Facility                      
Related party transactions                      
Face amount of debt at time of related party stock purchase               $ 60,000